research use only

DL-Homocysteine Transferase inhibitor

Name: DL-Homocysteine
Brand: Selleck Chemicals
SKU: S2994
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S2994

DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. This compound inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II.

Chemical Structure

Molecular Weight: 135.18

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.80%

99.80

Related Targets	P450 (e.g. CYP17) Dehydrogenase PDE phosphatase PPAR HSP (HSP90) Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase Serine/threonin kinase Lipoxygenase Phospholipase (e.g. PLA) Retinoid Receptor DPP ACE Peroxidases Amino Acids and Derivatives Fatty Acid Synthase FXR HMG-CoA Reductase Carbonic Anhydrase Lipase Decarboxylase DHFR IDO/TDO Hydroxylase PCSK9 OXPHOS ROR
Related Products	FK866 (Daporinad) GGTI 298 TFA salt AOA (Aminooxyacetic acid) hemihydrochloride Tunicamycin OSMI-4 A922500 FIDAS-3 SGN-2FF PF-04620110 ERG240 2-BP (2-Bromohexadecanoic acid) OSMI-1 FDFT1 Antibody [H17C4] ACAT1 Antibody [L1D14] Schisanhenol Curzerene Ezatiostat Hecogenin L002 (NSC764414) 3-Methoxybenzamide FIDAS-5 Cyclandelate HPRT Antibody [F5D11] Glutamine Synthetase Antibody [L12L23] GSTP1 Antibody [G13B3] OGT Antibody [P16F9] Aspartate Aminotransferase + FABP-1 Antibody [N24P14] Meclofenoxate (Centrophenoxine) HCl TST Antibody [C14G9] SHIN1(RZ-2994)

Chemical Information, Storage & Stability

Molecular Weight	135.18	Formula	C₄H₉NO₂S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	454-29-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	NC(CCS)C(O)=O

Solubility

In vitro
Batch:

Water : 27 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	KYNA ^[1] KAT ^[1]
In vivo	In vivo peripheral application of DL-homocysteine increases Kynurenic Acid (KYNA) content in cortex and hippocampus.^[2]
References	[1] https://pubmed.ncbi.nlm.nih.gov/15605380/ [2] https://pubmed.ncbi.nlm.nih.gov/15605380/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):