Home Proteases MMP activator Ginkgolide C

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Ginkgolide C MMP activator

Cat.No.S3781

Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. This compound can activate the AMPK signaling pathway and also promote the conversion of pro-MMP-9 to its active form MMP-9.
Ginkgolide C MMP activator Chemical Structure

Chemical Structure

Molecular Weight: 440.40

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Quality Control

Batch: S378101 DMSO]88 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 440.40 Formula

C20H24O11

 Storage (From the date of receipt)
CAS No. 15291-76-6 Download SDF Storage of Stock Solutions

Solubility

In vitro
Batch:

DMSO : 88 mg/mL ( (199.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
MMP-9 [3]
In vitro

Ginkgolide C significantly suppresses lipid accumulation in differentiated adipocytes. It also decreases adipogenesis-related transcription factor expression, including peroxisome proliferator-activated receptor and CCAAT/enhancer-binding protein. Furthermore, this compound enhances adipose triglyceride lipase and hormone-sensitive lipase production for lipolysis and increases phosphorylation of AMP-activated protein kinase (AMPK), resulting in decreased activity of acetyl-CoA carboxylase for fatty acid synthesis[1].
References

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