For research use only.
Catalog No.S3930 Synonyms: Liquiritoside, Liquiritigenin-4'-O-glucoside
CAS No. 551-15-5
Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
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|Description||Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.|
Liquiritin exerts neuroprotective and neurotrophic effects on primary cultured hippocampal cells. Liquiritin may enhance cell survival by increasing the protein expression level of glucose-6 phosphate dehydrogenase. Liquiritin potentiates neurite outgrowth induced by nerve growth factor in PC12 cells. It affects particular types of cells such as neurons in the central nervous system. Liquiritin increases the proliferation of B65 neuroblastoma cells.
|In vivo||Liquiritin at doses of 50-100 mg/kg significantly improves the cognitive ability, restores the abnormal activities of glutathione peroxidase and superoxide dismutase, and decreases the levels of malondialdehyde，8-hydroxy-2′-deoxyguanosine and protein carbonyl in the hippocampus of rats with Alzheimer's disease. Liquiritin can significantly ameliorate Aβ1-42-induced spatial learning and memory impairment by inhibiting oxidative stress and neural apoptosis. It is also frequently used to treat injury or swelling owing to its life-enhancing properties, as well as detoxification in traditional oriental medicine. It exerts significant antidepressant-like effects on the forced swimming and tail suspension tests in mice. It can also produce obvious neuroprotective effects on focal cerebral ischemia/reperfusion induced by middle cerebral artery occlusion. Liquiritin can protect neurons from Aβ-induced neurotoxicity. This ability probably involves the suppression of oxidative stress and neuron apoptosis in a rat model of Alzheimer disease (AD) induced by subsequent bilateral intrahippocampal (IH) injections of aggregated soluble oligomeric Aβ1-42. Liquiritin provides beneficial effects on the cognitive impairments observed in an Aβ1-42-induced model of AD. The neuroprotective effects of liquiritin are closely associated with its effects of inhibiting oxidative stress and neuronal apoptosis.|
|In vitro||DMSO||100 mg/mL (239.01 mM)|
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