Liquiritin

For research use only.

Catalog No.S3930 Synonyms: Liquiritoside, Liquiritigenin-4'-O-glucoside

Liquiritin Chemical Structure

CAS No. 551-15-5

Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.

Purity & Quality Control

Choose Selective AKR1C Inhibitors

Biological Activity

Description Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
In vitro

Liquiritin exerts neuroprotective and neurotrophic effects on primary cultured hippocampal cells[1]. Liquiritin may enhance cell survival by increasing the protein expression level of glucose-6 phosphate dehydrogenase. Liquiritin potentiates neurite outgrowth induced by nerve growth factor in PC12 cells. It affects particular types of cells such as neurons in the central nervous system. Liquiritin increases the proliferation of B65 neuroblastoma cells[2].

In vivo Liquiritin at doses of 50-100 mg/kg significantly improves the cognitive ability, restores the abnormal activities of glutathione peroxidase and superoxide dismutase, and decreases the levels of malondialdehyde,8-hydroxy-2′-deoxyguanosine and protein carbonyl in the hippocampus of rats with Alzheimer's disease. Liquiritin can significantly ameliorate Aβ1-42-induced spatial learning and memory impairment by inhibiting oxidative stress and neural apoptosis. It is also frequently used to treat injury or swelling owing to its life-enhancing properties, as well as detoxification in traditional oriental medicine. It exerts significant antidepressant-like effects on the forced swimming and tail suspension tests in mice. It can also produce obvious neuroprotective effects on focal cerebral ischemia/reperfusion induced by middle cerebral artery occlusion. Liquiritin can protect neurons from Aβ-induced neurotoxicity. This ability probably involves the suppression of oxidative stress and neuron apoptosis in a rat model of Alzheimer disease (AD) induced by subsequent bilateral intrahippocampal (IH) injections of aggregated soluble oligomeric Aβ1-42. Liquiritin provides beneficial effects on the cognitive impairments observed in an Aβ1-42-induced model of AD. The neuroprotective effects of liquiritin are closely associated with its effects of inhibiting oxidative stress and neuronal apoptosis[1].

Protocol

Cell Research:[2]
- Collapse
  • Cell lines: B65 neuroblastoma cells
  • Concentrations: --
  • Incubation Time: 24, 48 and 72 h
  • Method: The proliferation of B65 neuroblastoma cells was investigated by a WST-8 assay using a Cell Counting Kit-8. Once cells became confluent, they were plated into 96-well microplates at a density of 5×104/mL (5×103/well) and incubated with glycyrrhizin, isoliquiritin and liquiritin, which were first dissolved in dimethyl sulfoxide (DMSO). When cells were treated with these compounds, the final concentration of DMSO was set at 0.1% in the culture medium. When cells were treated with various cytotoxic reagents, such as hydrogen peroxide, monosodium glutamate, or menadione sodium bisulfate, these agents were directly dissolved in culture media following the description in each experiment. In general, this assay was performed after cells were cultured with each compound or reagent for 24, 48 and 72 h. After culture, the cells were incubated with WST-8 solution at 37℃ for 2 h, and the spectrophotometric absorbance of WST-8-formazan produced by dehydrogenase activity in the living cells at 450 nm.
    (Only for Reference)
Animal Research:[1]
- Collapse
  • Animal Models: Adult male Sprague-Dawley rats
  • Dosages: 100, 50, or 25 mg/kg
  • Administration: orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (239.01 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 418.39
Formula

C21H22O9

CAS No. 551-15-5
Storage powder
in solvent
Synonyms Liquiritoside, Liquiritigenin-4'-O-glucoside
Smiles C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Liquiritin | Liquiritin supplier | purchase Liquiritin | Liquiritin cost | Liquiritin manufacturer | order Liquiritin | Liquiritin distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID