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Liquiritin AKR1C inhibitor

Cat.No.S3930

Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
Liquiritin AKR1C inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 418.39

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Quality Control

Batch: S393001 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.85%
99.85

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (239.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 418.39 Formula

C21H22O9

 Storage (From the date of receipt)
CAS No. 551-15-5 Download SDF Storage of Stock Solutions

Synonyms Liquiritoside, Liquiritigenin-4'-O-glucoside Smiles C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O

Mechanism of Action

In vitro
Liquiritin exerts neuroprotective and neurotrophic effects on primary cultured hippocampal cells. This compound may enhance cell survival by increasing the protein expression level of glucose-6 phosphate dehydrogenase. It potentiates neurite outgrowth induced by nerve growth factor in PC12 cells. It affects particular types of cells such as neurons in the central nervous system. This chemical increases the proliferation of B65 neuroblastoma cells.
In vivo
Liquiritin at doses of 50-100 mg/kg significantly improves the cognitive ability, restores the abnormal activities of glutathione peroxidase and superoxide dismutase, and decreases the levels of malondialdehyde，8-hydroxy-2′-deoxyguanosine and protein carbonyl in the hippocampus of rats with Alzheimer's disease. This compound can significantly ameliorate Aβ1-42-induced spatial learning and memory impairment by inhibiting oxidative stress and neural apoptosis. It is also frequently used to treat injury or swelling owing to its life-enhancing properties, as well as detoxification in traditional oriental medicine. It exerts significant antidepressant-like effects on the forced swimming and tail suspension tests in mice. It can also produce obvious neuroprotective effects on focal cerebral ischemia/reperfusion induced by middle cerebral artery occlusion. This chemical can protect neurons from Aβ-induced neurotoxicity. This ability probably involves the suppression of oxidative stress and neuron apoptosis in a rat model of Alzheimer disease (AD) induced by subsequent bilateral intrahippocampal (IH) injections of aggregated soluble oligomeric Aβ1-42. It provides beneficial effects on the cognitive impairments observed in an Aβ1-42-induced model of AD. The neuroprotective effects of this compound are closely associated with its effects of inhibiting oxidative stress and neuronal apoptosis.
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