Trans-Anethole

Catalog No.S3990 Synonyms: 4-Propenylanisole

For research use only.

Trans-anethole (4-Propenylanisole) is a phenylpropene derivative found in many essential oils, including anise oil. It has neuromodulatory, anxiolytic, antioxidative, antifungal, anti-inflammatory, and immunomodulatory activities.

Trans-Anethole Chemical Structure

CAS No. 4180-23-8

Purity & Quality Control

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Biological Activity

Description Trans-anethole (4-Propenylanisole) is a phenylpropene derivative found in many essential oils, including anise oil. It has neuromodulatory, anxiolytic, antioxidative, antifungal, anti-inflammatory, and immunomodulatory activities.
In vitro

Trans-anethole markedly reduces neuronal cell death induced by oxygen-glucose deprivation/reoxygenation (OGD/R), an in vitro model of cerebral ischemia. Thus, trans-anethole is a neuroprotective agent to ameliorate ischemic neuronal damage[1].

In vivo Pretreatment with trans-anethole can lead to moderate protective effects against in vivo genotoxicity[2].

Protocol (from reference)

Animal Research:

[2]

  • Animal Models: Male swiss albino mice
  • Dosages: 40-400 mg/kg
  • Administration: by gavage
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 29 mg/mL
(195.68 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 148.20
Formula

C10H12O

Density 0.988 g/mL
CAS No. 4180-23-8
Storage 2 years -20°C liquid
Smiles CC=CC1=CC=C(C=C1)OC

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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