Solanesol (Nonaisoprenol)

Catalog No.S2360 Synonyms: Nonaisoprenol, Betulanonaprenol

For research use only.

Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.

Solanesol (Nonaisoprenol) Chemical Structure

CAS No. 13190-97-1

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Biological Activity

Description Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
Targets
FAK [1]
In vitro

Solanesol is widely used as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities. Solanesol binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK)[1]. Solanesol upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. Solanesol also inhibits LDH, AST, MDA and ROS level, but increases the GSH level and promotes tBHQ-mediated protective effects[2].

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: normal human hepatic cell L02
  • Concentrations: 10, 50, 100, 250, 500, 1000 μM
  • Incubation Time: 12 h
  • Method:

    Cell viability is determined by MTT assays. Cells are seeded into 96-well plates (5 × 104 cells/well) 24 h before treatment. The cells are then treated with various concentrations of solanesol followed by incubating with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals, the cells are detected under an Microplate Reader to measure the absorbance at 570 nm.

Animal Research:

[3]

  • Animal Models: Male albino rats
  • Dosages: 0.2 g of gel containing solanesol (1 % w/v)
  • Administration: applied to the plantar surface of the right hind paw by gently rubbing with the index finger

Chemical Information

Molecular Weight 631.07
Formula

C45H74O

CAS No. 13190-97-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCO)C)C)C)C)C)C)C)C)C

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