Home Angiogenesis FAK inhibitor Solanesol (Nonaisoprenol)

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Solanesol (Nonaisoprenol) FAK inhibitor

Cat.No.S2360

Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
Solanesol (Nonaisoprenol) FAK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 631.07

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Quality Control

Batch: S236001 DMSO]25 mg/mL]true]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.05%
99.05

Solubility

In vitro
Batch:

DMSO : 25 mg/mL (39.61 mM) Warmed with 50°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 631.07 Formula

C45H74O

 Storage (From the date of receipt)
CAS No. 13190-97-1 Download SDF Storage of Stock Solutions

Synonyms Nonaisoprenol, Betulanonaprenol Smiles CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCO)C)C)C)C)C)C)C)C)C

Mechanism of Action

Targets/IC50/Ki
FAK
In vitro
Solanesol (Nonaisoprenol) is widely used as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities. This compound binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK). It upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. It also inhibits LDH, AST, MDA and ROS level, but increases the GSH level and promotes tBHQ-mediated protective effects.
References

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