Solanesol (Nonaisoprenol)

For research use only.

Catalog No.S2360 Synonyms: Nonaisoprenol, Betulanonaprenol

Solanesol (Nonaisoprenol) Chemical Structure

CAS No. 13190-97-1

Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.

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Biological Activity

Description Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
Targets
FAK [1]
()
In vitro

Solanesol is widely used as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities. Solanesol binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK)[1]. Solanesol upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. Solanesol also inhibits LDH, AST, MDA and ROS level, but increases the GSH level and promotes tBHQ-mediated protective effects[2].

Protocol

Cell Research:

[2]

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  • Cell lines: normal human hepatic cell L02
  • Concentrations: 10, 50, 100, 250, 500, 1000 μM
  • Incubation Time: 12 h
  • Method:

    Cell viability is determined by MTT assays. Cells are seeded into 96-well plates (5 × 104 cells/well) 24 h before treatment. The cells are then treated with various concentrations of solanesol followed by incubating with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals, the cells are detected under an Microplate Reader to measure the absorbance at 570 nm.


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: Male albino rats
  • Dosages: 0.2 g of gel containing solanesol (1 % w/v)
  • Administration: applied to the plantar surface of the right hind paw by gently rubbing with the index finger
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 631.07
Formula

C45H74O

CAS No. 13190-97-1
Storage powder
in solvent
Synonyms Nonaisoprenol, Betulanonaprenol
Smiles CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCO)C)C)C)C)C)C)C)C)C

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FAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID