Myricetin

Catalog No.S2326 Synonyms: Cannabiscetin

For research use only.

Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.

Myricetin Chemical Structure

CAS No. 529-44-2

Selleck's Myricetin has been cited by 7 Publications

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Biological Activity

Description Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.
Targets
MEK1 [4] PI3Kγ [5]
0.17 μM(Kd)
In vitro

Myricetin(Cannabiscetin) is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties. Myricetin has antioxidant properties. In vitro research suggests that myricetin in high concentrations can modify LDL cholesterol such that uptake by white blood cells is increased. [1] Studies shows that high myricetin consumption reduces the risk of prostate cancer and pancreatic cancer. [2] [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HT-29 cells NEjWXnZHfW6ldHnvckBie3OjeR?= MnPmSIV{\W6|aYTpfoF1cW:wIH;mJGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIFjUMVI6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gfoFxemmwYYP0MYlv\HWlZXSg[Jlv[W2rYzDtZZN{KHKnZHnzeJJq[nW2aX;uJIFnfGW{IEGwJI1qdnNuIFnDOVA:Oi5zMjFOwG0> MljINlQ6ODB2NEe=
HeLa cells MW\GeY5kfGmxbjDhd5NigQ>? MU\Jcohq[mm2aX;uJI9nKE2UUEGgeJJidnOoZXP0[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG3MWGM1KHS{YX7zdI9zfCCkeTDyZZBq\CCoaXz0doF1cW:wIHHzd4F6NCCNaU2yMlQh|ryP NIjp[WMyQTd{NUW3PC=>
HCT116 cells NYWxUXRNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXq0PEBp NVTxPHZtT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;ND6xJO69VQ>? MnfNNlIzOTJ5MkG=
human 22Rv1 cells NEjF[ZlRem:uaX\ldoF1cW:wIHHzd4F6 MoX0NVQ1KGh? NVz4S2ZTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjCyNnJ3OSClZXzsd{BqdmO3YnH0[YQhfXBidH:gNVQ1KGi{czDifUBEd3WudHXyJJBienSrY3zlJINwfW62IHHu[EB{cXqnIHHuZYx6gmW{LDDJR|UxRTF|LkGg{txO MnjzNlI4QDl6MUK=
human SKBR3 cells NEjGXmpHfW6ldHnvckBie3OjeR?= Mk\DNlQhcA>? NU\Hc4M6TGm|cHzhZ4Vu\W62IH;mJGdONWO7M1Kg[pJwdSCKc4C5NEBqdiCqdX3hckBUU0KUMzDj[YxteyCjZoTldkAzPCCqcoOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OD1zMz61JO69VQ>? MoHiNlQ2PDh{MEe=
human U2OS cells M3PrXWZ2dmO2aX;uJIF{e2G7 M2TQTlUhcA>? MWXB[49vcXO2IHHjeIl3cXS7IHH0JGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIGWyU3Mh[2WubIOgZ49mgHC{ZYPzbY5oKEejbEStWnAyPi2WRW[gZZN{\XO|ZXSgZZMh[mW2YTDhdpJme3SrbjD0doFve2yxY3H0bY9vKGGodHXyJFUhcHK|IHL5JIJmfGFibHHjeIFu[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MUSuO{DPxE1? NIGyV5IzPDlyMES0Oy=>
human H9 cells NXnZTHk5TnWwY4Tpc44h[XO|YYm= M2rTSVMh\GG7cx?= NGnVSo1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlv\mWldHXkJIlvKGi3bXHuJGg6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IICyOEBidnSrZ3XuJINieHS3cnWgZZN{[XluIFXDOVA:OzVizszN NEfjUmI5OTV6MU[0
NCI-60 human tumor cell line NX74RnFxS3m2b4TvfIlkcXS7IHHzd4F6 NWixT3dmUW5idnn0do8h[3m2b4TvfIlkKHCxdHXuZ5kh[WejaX7zeEBPS0lvNkCgbJVu[W5idIXtc5Ih[2WubDDsbY5mNCCJSUWwQVM3KM7:TR?= MV25OlMzOzZ4
human HL60 cells NV7KWGoxWHKxbHnm[ZJifGmxbjDhd5NigQ>? MWCzNEDPxE1? NXKyVWltPDhiaB?= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYSgN|AhfU1iYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigQ>? NYP0eWg3OTh{NUi0OFA>
mouse L929 cells NFuxU49HfW6ldHnvckBie3OjeR?= Mn\xNkBp NUDvdoU5UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDUUmYu[WyyaHGtbY5lfWOnZDDjfZRwfG:6aXPpeJkhd2ZibX;1d4UhVDl{OTDj[YxteyCjc4Pld5Nm\CCjczDzeZJ3cX[jbHn0fUB1emWjdHXkJJdqfGhiZIL1[{Bi\nSncjCyJIhzeyCxZjDUUmZidHCqYTD0doVifG2nboS= M17LdlkzQDd2MUW=

Protocol (from reference)

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

5mg/mL

Chemical Information

Molecular Weight 318.24
Formula

C15H10O8

CAS No. 529-44-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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