Myricetin

For research use only.

Catalog No.S2326 Synonyms: Cannabiscetin

6 publications

Myricetin Chemical Structure

CAS No. 529-44-2

Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.

Selleck's Myricetin has been cited by 6 publications

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Biological Activity

Description Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.
Targets
MEK1 [4] PI3Kγ [5]
0.17 μM(Kd)
In vitro

Myricetin(Cannabiscetin) is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties. Myricetin has antioxidant properties. In vitro research suggests that myricetin in high concentrations can modify LDL cholesterol such that uptake by white blood cells is increased. [1] Studies shows that high myricetin consumption reduces the risk of prostate cancer and pancreatic cancer. [2] [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HT-29 cells NYPtcm9xTnWwY4Tpc44h[XO|YYm= NIL6d2tF\XOnboPpeIl7[XSrb36gc4YhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gTHQuOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB7[XC{aX7hd5QucW6mdXPl[EBlgW6jbXnjJI1ie3NicnXkbZN1emmkdYTpc44h[W[2ZYKgNVAhdWmwczygTWM2OD1{LkGyJO69VQ>? MYWyOFkxODR2Nx?=
HeLa cells MVTGeY5kfGmxbjDhd5NigQ>? Mm\1TY5pcWKrdHnvckBw\iCPUmCxJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM1jdUHREPCC2cnHud5BwenRiYomgdoFxcWRiZnnseJJifGmxbjDhd5NigSxiS3m9Nk41KM7:TR?= MkHNNVk4OjV3N{i=
HCT116 cells NYrue3RqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUe4T41RPDhiaB?= M3zPTmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCxdnXy[ZhxemW|c3nu[{BRUTONYXzwbIEhUDFyNEfSJI12fGGwdDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTRwMTFOwG0> NHLmd3QzOjJzMkeyNS=>
human 22Rv1 cells NID5VVBRem:uaX\ldoF1cW:wIHHzd4F6 NXnme5VWOTR2IHi= NWO1XWVUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjCyNnJ3OSClZXzsd{BqdmO3YnH0[YQhfXBidH:gNVQ1KGi{czDifUBEd3WudHXyJJBienSrY3zlJINwfW62IHHu[EB{cXqnIHHuZYx6gmW{LDDJR|UxRTF|LkGg{txO MWiyNlc5QThzMh?=
human SKBR3 cells MV;GeY5kfGmxbjDhd5NigQ>? M1nMOlI1KGh? M2rDVmRqe3CuYXPlcYVvfCCxZjDHUU1kgTOEIH\yc40hUHOyOUCgbY4hcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVA:OTNwNTFOwG0> Ml\LNlQ2PDh{MEe=
human U2OS cells M4K5dGZ2dmO2aX;uJIF{e2G7 MkDsOUBp NUjrbHVLSWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBWOk:VIHPlcIx{KGOxZYjwdoV{e2mwZzDHZYw1NV[SMU[tWGVXKGG|c3Xzd4VlKGG|IHLleIEh[XK{ZYP0bY4hfHKjboPsc4NifGmxbjDh[pRmeiB3IHjyd{BjgSCkZYThJIxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVE1NjdizszN MYWyOFkxODR2Nx?=
human H9 cells NUTobZVETnWwY4Tpc44h[XO|YYm= NV3iWllKOyCmYYnz MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIFi5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KHB{NDDhcpRq\2WwIHPhdJR2emViYYPzZZktKEWFNUC9N|Uh|ryP NXf1R2ZWQDF3OEG2OC=>
NCI-60 human tumor cell line MmD2R5l1d3SxeHnjbZR6KGG|c3H5 NWPSSFJ3UW5idnn0do8h[3m2b4TvfIlkKHCxdHXuZ5kh[WejaX7zeEBPS0lvNkCgbJVu[W5idIXtc5Ih[2WubDDsbY5mNCCJSUWwQVM3KM7:TR?= M3\1bFk3OzJ|Nk[=
human HL60 cells NVvjb5E2WHKxbHnm[ZJifGmxbjDhd5NigQ>? NVTMbmpvOzBizszN MmDUOFghcA>? NUnyRmlmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF1KDNyIIXNJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYm= MWexPFI2QDR2MB?=
mouse L929 cells MWfGeY5kfGmxbjDhd5NigQ>? MmP5NkBp M4rwXmlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iVF7GMYFteGijLXnu[JVk\WRiY4n0c5RwgGmlaYT5JI9nKG2xdYPlJGw6OjliY3XscJMh[XO|ZYPz[YQh[XNic4Xyeol3[WyrdImgeJJm[XSnZDD3bZRpKGS{dXegZYZ1\XJiMjDodpMhd2ZiVF7GZYxxcGFidILlZZRu\W62 NE\STIc6Ojh5NEG1

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 63 mg/mL (197.96 mM)
Ethanol 9 mg/mL warmed (28.28 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 318.24
Formula

C15H10O8

CAS No. 529-44-2
Storage powder
in solvent
Synonyms Cannabiscetin
Smiles C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID