Wilforine

Catalog No.S0921 Synonyms: WR

For research use only.

Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).

Wilforine Chemical Structure

CAS No. 11088-09-8

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Biological Activity

Description Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
Targets
P-gp [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 867.85
Formula

C43H49NO18

CAS No. 11088-09-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CCC2=C(C=CC=N2)C(=O)OCC3(C4C(C(C5(C(C(C(C(C5(C4OC(=O)C)O3)(C)O)OC1=O)OC(=O)C6=CC=CC=C6)OC(=O)C)COC(=O)C)OC(=O)C)OC(=O)C)C

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05109364 Not yet recruiting Drug: Terazosin therapy Symptomatic Parkinson Disease|REM Sleep Behavior Disorder|Pre-motor Parkinson''s Disease Cedars-Sinai Medical Center November 23 2021 Phase 2
NCT04826497 Not yet recruiting Drug: nicorandil|Drug: Placebo(normal saline) Coronary Heart Disease Xuzhou Central Hospital April 2021 Phase 4
NCT04386317 Recruiting Drug: Terazosin REM Sleep Behavior Disorder|Pre-motor Parkinson''s Disease|Symptomatic Parkinson Disease Cedars-Sinai Medical Center November 1 2020 Phase 2
NCT04629664 Completed Drug: FX-322|Other: Placebo Hearing Loss Sensorineural|Noise Induced Hearing Loss|Sudden Hearing Loss Frequency Therapeutics November 2 2020 Phase 1
NCT04601909 Completed Drug: FX-322|Other: placebo Presbycusis|Hearing Loss Sensorineural|Noise Induced Hearing Loss|Sudden Hearing Loss Frequency Therapeutics September 17 2020 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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