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Wilforine P-gp inhibitor

Cat.No.S0921

Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
Wilforine P-gp inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 867.85

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Quality Control

Batch: S092101 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.93%
98.93

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (115.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 867.85 Formula

C43H49NO18

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 11088-09-8 -- Storage of Stock Solutions

Synonyms WR Smiles CC1CCC2=C(C=CC=N2)C(=O)OCC3(C4C(C(C5(C(C(C(C(C5(C4OC(=O)C)O3)(C)O)OC1=O)OC(=O)C6=CC=CC=C6)OC(=O)C)COC(=O)C)OC(=O)C)OC(=O)C)C

Mechanism of Action

Targets/IC50/Ki
P-gp
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05109364 Recruiting
Symptomatic Parkinson Disease|REM Sleep Behavior Disorder|Pre-motor Parkinson''s Disease
Cedars-Sinai Medical Center
 September 23 2022 Phase 2
NCT04826497 Unknown status
Coronary Heart Disease
Xuzhou Central Hospital
 April 2021 Phase 4
NCT04386317 Recruiting
REM Sleep Behavior Disorder|Pre-motor Parkinson''s Disease|Symptomatic Parkinson Disease
Cedars-Sinai Medical Center
 November 1 2020 Phase 2
NCT04629664 Completed
Hearing Loss Sensorineural|Noise Induced Hearing Loss|Sudden Hearing Loss
Frequency Therapeutics
 November 2 2020 Phase 1
NCT04601909 Completed
Presbycusis|Hearing Loss Sensorineural|Noise Induced Hearing Loss|Sudden Hearing Loss
Frequency Therapeutics
 September 17 2020 Phase 1

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