For research use only. Not for use in humans.
Catalog No.S2343 Synonyms: Phloridzin
Molecular Weight(MW): 436.41
Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees.
Selleck's Phlorizin has been cited by 5 publications
2 Customer Reviews
PQ increases glucose transport and the translocation of glucose transporters. Cells were treated with PQ for 48 h. The survival of cells treated with PQ in the presence or absence of phlorizin (e) was determined. Bar graph represents percents of viable cells (cell survival).
Mol Neurobiol, 2016, 54(5):3825-3842. Phlorizin purchased from Selleck.
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|Description||Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees.|
Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2; this reduces renal glucose transport, lowering the amount of glucose in the blood.  Phlorizin's principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine which benefits the treatment of diabetes, obesity, and stress hyperglycemia. 
|In vitro||DMSO||87 mg/mL warmed (199.35 mM)|
|Ethanol||9 mg/mL warmed (20.62 mM)|
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