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Glycine

Synonyms: 2-Aminoacetic acid, Aminoacetic acid, Glycocoll

Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.

Glycine Chemical Structure

Glycine Chemical Structure

CAS: 56-40-6

Selleck's Glycine has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.88%
99.88

Glycine Related Products

Biological Activity

Description Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.
Targets
MT2 receptor [1] MT1 receptor [1]
9.8(pKi) 9.45(pKi)
In vitro
In vitro Glycine significantly increases the MG-63 cell proliferation in a dosedependent manner. Activity of alkaline phosphatase (ALP) and phosphorylation of extracellular-signal-regulated kinase are increased by glycine in MG-63 cells. Glycine also increases the BrdU-incorporation and Ki-67 mRNA expression in MCF-7 cells, induces the up-regulation of estrogen receptor-β mRNA expression and estrogen response element-luciferase activity in MG-63 and MCF-7 cells[2].
Cell Research Cell lines MG-63 osteoblast cell line, MCF-7 estrogen-dependent cell line
Concentrations 0.1, 1, and 10 μg/ml
Incubation Time 48 h
Method

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In Vivo
In vivo Glycine is the most abundant amino acid in the body and is involved in multiple metabolic pathways. Circulating glycine levels in humans, rats and mice, cats, and dogs range from 0.2-0.4 mM. In rabbits and pigs, they are 1-1.5 mM. Intracellular concentrations are much higher, particularly in renal proximal tubules, which reabsorb filtered glycine and reach 4–10x circulating levels depending on whether they are being actively perfused. Glycine has been reported to lower blood pressure in an NMDA-sensitive fashion[1]. Glycine has an estrogen-like osteoprotective effect in menopause models. It significantly increases the ALP activity, enhances bone mineral density, trabecular number, and connectivity density in OVX mice[2].
Animal Research Animal Models Seven-week-old female Balb/c mice
Dosages 10 mg/kg
Administration orally
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05799651 Recruiting
SARS-CoV-2
Glycovax Pharma Inc.|Government of Canada|JSS Medical Research Inc.|Avance Clinical Pty Ltd.|Seppic
 April 28 2023 Phase 1
NCT06159322 Recruiting
Schizophrenia|Schizoaffective Disorder
The Royal Ottawa Mental Health Centre|The Royal''s Institute of Mental Health Research
 January 1 2023 --
NCT05900635 Recruiting
Anemia of Chronic Kidney Disease
Alexandria University
 October 1 2022 Phase 4
NCT05478525 Completed
Type 2 Diabetes
Glyscend Inc.
 August 3 2022 Phase 2
NCT05270525 Recruiting
COPD
Verona Pharma plc|University of Alabama at Birmingham
 May 27 2022 Phase 2

Chemical Information & Solubility

Molecular Weight 75.07 Formula

C2H5NO2
CAS No. 56-40-6 SDF Download Glycine SDF
Smiles C(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 15 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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