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Glycine iGluR chemical

Cat.No.S4821

Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.
Glycine iGluR chemical Chemical Structure

Chemical Structure

Molecular Weight: 75.07

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Quality Control

Batch: Purity: 99.88%
99.88

Solubility

In vitro
Batch:

Water : 15 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 75.07 Formula

C2H5NO2

 Storage (From the date of receipt)
CAS No. 56-40-6 Download SDF Storage of Stock Solutions

Synonyms 2-Aminoacetic acid, Aminoacetic acid, Glycocoll Smiles C(C(=O)O)N

Mechanism of Action

Targets/IC50/Ki
MT2 receptor
9.8(pKi)
MT1 receptor
9.45(pKi)
In vitro
Glycine significantly increases the MG-63 cell proliferation in a dosedependent manner. Activity of alkaline phosphatase (ALP) and phosphorylation of extracellular-signal-regulated kinase are increased by this compound in MG-63 cells. It also increases the BrdU-incorporation and Ki-67 mRNA expression in MCF-7 cells, induces the up-regulation of estrogen receptor-β mRNA expression and estrogen response element-luciferase activity in MG-63 and MCF-7 cells.
In vivo
Glycine is the most abundant amino acid in the body and is involved in multiple metabolic pathways. Circulating levels of this compound in humans, rats and mice, cats, and dogs range from 0.2-0.4 mM. In rabbits and pigs, they are 1-1.5 mM. Intracellular concentrations are much higher, particularly in renal proximal tubules, which reabsorb filtered glycine and reach 4–10x circulating levels depending on whether they are being actively perfused. It has been reported to lower blood pressure in an NMDA-sensitive fashion. This amino acid has an estrogen-like osteoprotective effect in menopause models. It significantly increases the ALP activity, enhances bone mineral density, trabecular number, and connectivity density in OVX mice.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06378346 Recruiting
Prostate Cancer
University of Illinois at Chicago
 May 2024 Phase 2
NCT06242535 Recruiting
Insulin Resistance|Obesity|Cardiovascular Diseases|Cognitive Impairment|Physical Disability|Depression|Inflammation|Hormone Deficiency|Physical Inactivity|Hyperlipidemias|Hypertension|Overeating
Hoskinson Health and Wellness Clinic|Buck Institute for Research on Aging|University of Wyoming
 July 27 2023 Early Phase 1
NCT05799651 Active not recruiting
SARS-CoV-2
Glycovax Pharma Inc.|Government of Canada|JSS Medical Research Inc.|Avance Clinical Pty Ltd.|Seppic
 April 28 2023 Phase 1

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