Berberine chloride

For research use only.

Catalog No.S2271

2 publications

Berberine chloride Chemical Structure

CAS No. 633-65-8

Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

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10mM (1mL in DMSO) USD 90 In stock
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Selleck's Berberine chloride has been cited by 2 publications

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Biological Activity

Description Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Targets
Caspase-3 [1]
()
Caspase-8 [1]
()
PARP [1]
()
cytochrome c [1]
()
cIAP1 [1]
()
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MRC5 cells NE\kNHhHfW6ldHnvckBie3OjeR?= MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKGmwIF3SR|Uh[2WubIOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD1yLk[4JO69VQ>? Mke3NVczOzl3OUS=
MRC5 cells M3nVNHBzd2yrZnXyZZRqd25iYYPzZZk> M2LK[lExKM7:TR?= MnvhOVQhcHK| MX7Jcohq[mm2aX;uJI9nKEiFTW[gdJJwdGmoZYLheIlwdiCrbjDNVmM2KGOnbHzzJIFnfGW{IEW0JIhzeyCyb4P0MYlv\mWldHnvckBifCBzMDD1UUBjgSCybHHxeYUh[XO|YYm= NV\1RVM1OTd{M{m1PVQ>
MRC5 cells MlPNVJJwdGmoZYLheIlwdiCjc4PhfS=> NGjqPGYyOCEQvF2= MVOyOEBp MX3Jcohq[mm2aX;uJI9nKEiFTW[gdJJwdGmoZYLheIlwdiCrbjDNVmM2KGOnbHzzJIFnfGW{IEK0JIhzeyCyb4P0MYlv\mWldHnvckBifCBzMDD1UUBjgSCybHHxeYUh[XO|YYm= MkizNVczOzl3OUS=
Bel7402 cells M1XPdWZ2dmO2aX;uJIF{e2G7 NW\kUI1iOTJiaB?= M1PEcmlv\HWldHnvckBw\iCORFzSJJBzd3SnaX6gbY4hcHWvYX6gRoVtPzRyMjDj[YxteyCjZoTldkAyOiCqcoOgZpkhWlRvUFPSJIF{e2G7IILlcIF1cX[nIITvJINwdnS{b3y= MVWxPVA6ODd4Nx?=
HepG2 cells NUK4PVVUTnWwY4Tpc44h[XO|YYm= M176[lExKHWpL33M NVzxSJNpOTJiaB?= NYLCN45NUW6mdXP0bY9vKG:oIFzEUHIheHKxdHXpckBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFExKHWpL33MJIFnfGW{IEGyJIhzeyCkeTDmcI94KGO7dH;t[ZRzgQ>? MYqxPVA6ODd4Nx?=
KB cells MVnDfZRwfG:6aXPpeJkh[XO|YYm= NUj1RYw4PzJiaB?= NEfmcGZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:Py5|MjFOwG0> NYr0[VVzOTFzNEGxNFU>
HL60 cells M2XaTmFxd3C2b4Ppd{Bie3OjeR?= NX\lV25sPDhiaILz NYPSOmFtUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IES4JIhzeyC3c3nu[{Bidm6neHnuJHYueHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{BjgSCIQVPTJIFv[Wy7c3nz NVfMS3FzOjB{MkexOFQ>
A549 cells NV\ESo86S3m2b4TvfIlkcXS7IHHzd4F6 M1fpNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliU2LCJIF{e2G7LDDJR|UxRTZwMkeg{txO M4WyR|IxPTl2OES4
SKOV3 cells MmXaR5l1d3SxeHnjbZR6KGG|c3H5 NWS3UJc1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYomgV3JDKGG|c3H5MEBKSzVyPUG2MlQ1KM7:TR?= NYnYeYFWOjB3OUS4OFg>
SK-MEL-2 cells MULDfZRwfG:6aXPpeJkh[XO|YYm= M2nNZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMNU2HTD2yJINmdGy|IHL5JHNTSiCjc4PhfUwhUUN3ME2xN{44PiEQvF2= NWPLfZBkOjB3OUS4OFg>
HCT15 cells NIjKU2ZEgXSxdH;4bYNqfHliYYPzZZk> MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{BjgSCVUlKgZZN{[XluIFnDOVA:OTZwNUmg{txO NV\4V4JrOjB3OUS4OFg>
CEM cells NX3sfoZES3m2b4TvfIlkcXS7IHHzd4F6 NVO0RYhIPDhiaILz NH3JZVlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBETU1iY3XscJMh\XiycnXzd4lv\yCpcnXlckBndHWxcnXzZ4VvfCCycn;0[YlvKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEOFNUC9Nk4xQSEQvF2= NFHz[ZQzOTJ7NUi5NS=>
human CEM cells NWH4Und4TnWwY4Tpc44h[XO|YYm= M13Ec|ch\GG7cx?= NYi1NlZ1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yNTDNU2khUHWvYX6gbY1ufW6xZHXmbYNq\W6leTD2bZJ2eyBzIF7MOE4{KGmwZnXjeIVlKGmwIHj1cYFvKEOHTTDj[YxteyCneIDy[ZN{cW6pIHfy[YVvKG[udX;y[ZNk\W62IIDyc5RmcW5iYYPz[ZN{\WRiYYOgdFI1KGGwdHnn[Y4heHKxZIXjeIlwdiCvZXHzeZJm\CB5IHThfZMheG:|dDDpcoZm[3Srb36gZpkhTUyLU1GsJGVEPTB;MD6xN{DPxE1? NWLld5pGOjF{OUW4PVE>
SKN cells NIHRXlJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXy3NkBp MnzFS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCVS16gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF0yPS56ODFOwG0> M2faclIyPDBzMUG0
RKN cells MonNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHrjZ5I1QCCqcoO= MUTHdo94fGhiaX7obYJqfGmxbjDh[4FqdnO2IHj1cYFvKFKNTjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwQVQ6NjZizszN MWeyNVQxOTFzNB?=
G402 cells NGTURYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;NZlVyPDhiaILz M163e2dzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iR{SwNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTFzLki3JO69VQ>? M4LEfVIyPDBzMUG0
A10 cells M4XmUGZ2dmO2aX;uJIF{e2G7 NInIS|g{OCEQvF2= NYeydIs1OjRiaILz NXvxdZlSTG:5boLl[5Vt[XSrb36gc4YhW2OmMjDtVm5CKGW6cILld5Nqd25iaX6gdoF1KEFzMDDj[YxteyCjdDCzNEB2VSCjZoTldkAzPCCqcoOgZpkheXWjboTpeIF1cX[nIGLUMXBEWiCjbnHsfZNqew>? MnXpNlE1ODFzMUS=
A10 cells MnLtSpVv[3Srb36gZZN{[Xl? NVHlTZBLOzBizszN MVqyOEBpenN? MoPoSI94diC{ZXf1cIF1cW:wIH;mJHBzcW1{IH3SUmEh\XiycnXzd4lwdiCrbjDyZZQhSTFyIHPlcIx{KGG2IEOwJJVOKGGodHXyJFI1KGi{czDifUByfWGwdHn0ZZRqfmViUmStVGNTKGGwYXz5d4l{ MUWyNVQxOTFzNB?=
A10 cells NUW2PGRSTnWwY4Tpc44h[XO|YYm= MWGzNEDPxE1? NIPReHQzPCCqcoO= M2XaXWRwf26{ZXf1cIF1cW:wIH;mJGlueGtibWLORUBmgHC{ZYPzbY9vKGmwIILheEBCOTBiY3XscJMh[XRiM{CgeW0h[W[2ZYKgNlQhcHK|IHL5JJF2[W62aYTheIl3\SCUVD3QR3Ih[W6jbInzbZM> M3ridlIyPDBzMUG0
HepG2-A16-CD81 cells MW\GeY5kfGmxbjDhd5NigQ>? M3[2PVExKM7:TR?= MorFUm9XSVKWSWO6JGFvfGmvYXzhdolidCCuaY\ldkB{fGGpZTDhZ5Rqfmm2eTDt[YF{fXKnZDDhd{BiKGe{ZXH0[ZIhfGijbjC1NEUhemWmdXP0bY9vKGmwIGDsZZNud2SrdX2gfY9mdGmrIIPjbIl7d262IHHy[YEhcW5iSHXwS|IuSTF4LVPEPFEh[2WubIOgZZQhOTC3TTDjc41xd3WwZDDjc45k\W62cnH0bY9vNCCmZYTldo1qdmWmIHL5JIludXWwbz3mcJVwemW|Y3XuZ4Uv MUeyNlA6PjFyMR?=
HepG2-A16-CD81 cells MoD5SpVv[3Srb36gZZN{[Xl? MmS4NVAh|ryP MWrOU3ZCWlSLU{qgRY51cW2jbHHybYFtKGyrdnXyJJN1[WenIHHjeIl3cXS7IH3lZZN2emWmIHHzJJJm\HWldHnvckBqdiCSbHHzcY9lcXWvIInv[YxqcSC|Y3jpfo9vfCCjcnXhJIlvKEincFeyMWEyPi2FREixJINmdGy|IHL5JIludXWwbz3mcJVwemW|Y3XuZ4UtKGGwZDDt[YRq[W5ic3PobZpwdnRic3n6[UBifCBzMIXNJINwdXCxdX7kJINwdmOnboTyZZRqd25uIFnDOVA:OC53NEig{txO Mk\CNlIxQTZzMEG=
HepG2 cells NHHPPGxHfW6ldHnvckBie3OjeR?= NEHSfpAyOCEQvF2= Mn;LOEBp NHrTRZNKdmO{ZXHz[UBqdiCDTWDLZYxxcGFicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFExKHWPIHHmeIVzKDRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrczDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcC=> MXeyN|A2QDFyNx?=
HepG2 cells M1jtS2Z2dmO2aX;uJIF{e2G7 MWSxNEDPxE1? M2PVbFQhcA>? Moj3TY5kemWjc3WgbY4hfG:2YXygRW1RU2GucHjhJIxmfmWuIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDFyIIXNJIFnfGW{IESgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpd{Bz\WyjdHn2[UB1dyC3boTy[YF1\WRiY3;ueJJwdA>? MWKyN|A2QDFyNx?=
HepG2 cells MWTGeY5kfGmxbjDhd5NigQ>? MY[yNEDPxE1? MkfwNlQhcHK| M4XSeGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMhdW:{cHjvcI9ocWOjbDDjbIFv\2W|IHH0JFIxKHWPIHHmeIVzKDJ2IHjyd{B2e2mwZzDIc4VkcHO2IEOzNlU5KHO2YXnubY5oKGK7IH\seY9z\XOlZX7j[UBucWO{b4Pjc5Bq[yCjbnHsfZNqew>? MWKyN|E5OjB6OB?=
HT-29 cells NXPHbYZ6S3m2b4TvfIlkcXS7IHHzd4F6 MnnSOFghcHK| NWDDUlNjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF05NjR3IN88US=> MUGyN|E5OjB6OB?=
HepG2 cells NHvsSnBEgXSxdH;4bYNqfHliYYPzZZk> MUWyOEBpenN? Mkf6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNU4zOiEQvF2= Mmf0NlMyQDJyOEi=
HepG2 cells MYLDfZRwfG:6aXPpeJkh[XO|YYm= NV;EbodpPDhiaILz MmnxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME24MlMzKM7:TR?= M4\MU|I{OTh{MEi4

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 40 mg/mL (107.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
3mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.81
Formula

C20H18NO4.Cl

CAS No. 633-65-8
Storage powder
in solvent
Synonyms N/A
Smiles COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03281096 Recruiting Drug: Berberine hydrochloride|Drug: Placebo Colorectal Adenomas xiaohua li|Xijing Hospital of Digestive Diseases August 29 2017 Phase 2|Phase 3
NCT02806999 Unknown status Drug: Berberine; Insulin|Drug: Insulin Hyperglycemia Guangdong Provincial People''s Hospital July 2016 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID