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Berberine chloride

For research use only.

Catalog No.S2271

3 publications

Berberine chloride Chemical Structure

CAS No. 633-65-8

Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 88 In stock
EUR 68 In stock
EUR 206 In stock
EUR 461 In stock
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Selleck's Berberine chloride has been cited by 3 publications

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Biological Activity

Description Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Targets
Caspase-3 [1]
()
Caspase-8 [1]
()
PARP [1]
()
cytochrome c [1]
()
cIAP1 [1]
()
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MRC5 cells NFPvbZhHfW6ldHnvckBie3OjeR?= MY\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKGmwIF3SR|Uh[2WubIOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD1yLk[4JO69VQ>? MmL1NVczOzl3OUS=
MRC5 cells NFHEOJpRem:uaX\ldoF1cW:wIHHzd4F6 Mo\QNVAh|ryP M3LFV|U1KGi{cx?= NHPZN2JKdmirYnn0bY9vKG:oIFjDUXYheHKxbHnm[ZJifGmxbjDpckBOWkN3IHPlcIx{KGGodHXyJFU1KGi{czDwc5N1NWmwZnXjeIlwdiCjdDCxNEB2VSCkeTDwcIFyfWViYYPzZZk> MWCxO|I{QTV7NB?=
MRC5 cells MVnQdo9tcW[ncnH0bY9vKGG|c3H5 NXjDR2E{OTBizszN MWqyOEBp NGLYU2lKdmirYnn0bY9vKG:oIFjDUXYheHKxbHnm[ZJifGmxbjDpckBOWkN3IHPlcIx{KGGodHXyJFI1KGi{czDwc5N1NWmwZnXjeIlwdiCjdDCxNEB2VSCkeTDwcIFyfWViYYPzZZk> M3v1bFE4OjN7NUm0
Bel7402 cells M4\SfmZ2dmO2aX;uJIF{e2G7 MojaNVIhcA>? Mn7WTY5lfWO2aX;uJI9nKEyGTGKgdJJwfGWrbjDpckBpfW2jbjDC[Yw4PDB{IHPlcIx{KGGodHXyJFEzKGi{czDifUBTXC2SQ2KgZZN{[XlicnXsZZRqfmVidH:gZ49vfHKxbB?= NHPZXYUyQTB7MEe2Oy=>
HepG2 cells MVzGeY5kfGmxbjDhd5NigQ>? M3LjNVExKHWpL33M MnLBNVIhcA>? NU\3WI03UW6mdXP0bY9vKG:oIFzEUHIheHKxdHXpckBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFExKHWpL33MJIFnfGW{IEGyJIhzeyCkeTDmcI94KGO7dH;t[ZRzgQ>? NEXqUJMyQTB7MEe2Oy=>
KB cells M{jmRWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX[3NkBp MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUC9O{4{OiEQvF2= NEe0UY4yOTF2MUGwOS=>
HL60 cells NGnITIdCeG:ydH;zbZMh[XO|YYm= NFjjbG41QCCqcoO= NYP0R|RqUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IES4JIhzeyC3c3nu[{Bidm6neHnuJHYueHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{BjgSCIQVPTJIFv[Wy7c3nz NFSzSnYzODJ{N{G0OC=>
A549 cells NXLpN49MS3m2b4TvfIlkcXS7IHHzd4F6 NGq1eJVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IGPSRkBie3OjeTygTWM2OD14LkK3JO69VQ>? MUiyNFU6PDh2OB?=
SKOV3 cells NHXRcldEgXSxdH;4bYNqfHliYYPzZZk> MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BjgSCVUlKgZZN{[XluIFnDOVA:OTZwNESg{txO M4S1ZVIxPTl2OES4
SK-MEL-2 cells MkHBR5l1d3SxeHnjbZR6KGG|c3H5 Mmj4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suVUWOLUKgZ4VtdHNiYomgV3JDKGG|c3H5MEBKSzVyPUGzMlc3KM7:TR?= MnL3NlA2QTR6NEi=
HCT15 cells NHH3dmtEgXSxdH;4bYNqfHliYYPzZZk> NXu5VlJiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUWgZ4VtdHNiYomgV3JDKGG|c3H5MEBKSzVyPUG2MlU6KM7:TR?= MUWyNFU6PDh2OB?=
CEM cells MkPBR5l1d3SxeHnjbZR6KGG|c3H5 NXfvcIRvPDhiaILz NH\LO|ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBETU1iY3XscJMh\XiycnXzd4lv\yCpcnXlckBndHWxcnXzZ4VvfCCycn;0[YlvKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEOFNUC9Nk4xQSEQvF2= MWqyNVI6PTh7MR?=
human CEM cells NUeyXZR6TnWwY4Tpc44h[XO|YYm= MlmwO{Bl[Xm| M3fVPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODViTV;JJGh2dWGwIHntcZVvd2SnZnnjbYVv[3lidnnyeZMhOSCQTESuN{Bqdm[nY4Tl[EBqdiCqdX3hckBETU1iY3XscJMh\XiycnXzd4lv\yCpcnXlckBndHWxcnXzZ4VvfCCycn;0[YlvKGG|c3Xzd4VlKGG|IICyOEBidnSrZ3XuJJBzd2S3Y4Tpc44hdWWjc4Xy[YQhPyCmYYnzJJBwe3RiaX7m[YN1cW:wIHL5JGVNUVODLDDFR|UxRTBwMUOg{txO MlrxNlEzQTV6OUG=
SKN cells M4fKOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXO3NkBp NYWwRnNRT3Kxd4ToJIlvcGmkaYTpc44h[WejaX7zeEBpfW2jbjDTT24h[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygS2k2OD1zNT64PEDPxE1? NVLwcFFPOjF2MEGxNVQ>
RKN cells NIK1UlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGH4WFQ1QCCqcoO= Mm\vS5Jwf3SqIHnubIljcXSrb36gZYdicW6|dDDoeY1idiCUS16gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF01QS54IN88US=> NEf2ZZMzOTRyMUGxOC=>
G402 cells MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXO0PEBpenN? MV;Hdo94fGhiaX7obYJqfGmxbjDh[4FqdnO2IHj1cYFvKEd2MEKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF0yOS56NzFOwG0> MmLaNlE1ODFzMUS=
A10 cells MWfGeY5kfGmxbjDhd5NigQ>? MkPQN|Ah|ryP NWW3N5hZOjRiaILz NGK4cGZFd3ewcnXneYxifGmxbjDv[kBU[2R{IH3SUmEh\XiycnXzd4lwdiCrbjDyZZQhSTFyIHPlcIx{KGG2IEOwJJVOKGGodHXyJFI1KGi{czDifUByfWGwdHn0ZZRqfmViUmStVGNTKGGwYXz5d4l{ M37hTFIyPDBzMUG0
A10 cells NYPNO3VwTnWwY4Tpc44h[XO|YYm= MX2zNEDPxE1? MlKzNlQhcHK| MnW5SI94diC{ZXf1cIF1cW:wIH;mJHBzcW1{IH3SUmEh\XiycnXzd4lwdiCrbjDyZZQhSTFyIHPlcIx{KGG2IEOwJJVOKGGodHXyJFI1KGi{czDifUByfWGwdHn0ZZRqfmViUmStVGNTKGGwYXz5d4l{ MWiyNVQxOTFzNB?=
A10 cells M4\BXWZ2dmO2aX;uJIF{e2G7 MVGzNEDPxE1? MlG1NlQhcHK| NVj5W|BnTG:5boLl[5Vt[XSrb36gc4YhUW2yazDtVm5CKGW6cILld5Nqd25iaX6gdoF1KEFzMDDj[YxteyCjdDCzNEB2VSCjZoTldkAzPCCqcoOgZpkheXWjboTpeIF1cX[nIGLUMXBEWiCjbnHsfZNqew>? MW[yNVQxOTFzNB?=
HepG2-A16-CD81 cells NWnkdXpSTnWwY4Tpc44h[XO|YYm= NEXtfowyOCEQvF2= M1r3NG5QXkGUVFnTPkBCdnSrbXHsZZJq[WxibHn2[ZIhe3SjZ3WgZYN1cX[rdImgcYVie3W{ZXSgZZMh[SCpcnXheIVzKHSqYX6gOVAmKHKnZIXjeIlwdiCrbjDQcIF{dW:maYXtJJlw\WyraTDzZ4hqgm:wdDDhdoViKGmwIFjldGczNUFzNj3DSFgyKGOnbHzzJIF1KDFydV2gZ49ueG:3bnSgZ49v[2WwdILheIlwdixiZHX0[ZJucW6nZDDifUBqdW23bn:t[ox2d3Knc3PlcoNmNg>? MmXqNlIxQTZzMEG=
HepG2-A16-CD81 cells MYDGeY5kfGmxbjDhd5NigQ>? NH\RTngyOCEQvF2= MnHNUm9XSVKWSWO6JGFvfGmvYXzhdolidCCuaY\ldkB{fGGpZTDhZ5Rqfmm2eTDt[YF{fXKnZDDhd{Bz\WS3Y4Tpc44hcW5iUHzhd41w\Gm3bTD5c4VtcWlic3PobZpwdnRiYYLlZUBqdiCKZYDHNk1COTZvQ1S4NUBk\WyuczDifUBqdW23bn:t[ox2d3Knc3PlcoNmNCCjbnSgcYVlcWGwIIPjbIl7d262IIPpfoUh[XRiMUD1UUBkd22yb4Xu[EBkd26lZX70doF1cW:wLDDJR|UxRTBwNUS4JO69VQ>? NWC3e3p2OjJyOU[xNFE>
HepG2 cells NXXpWJZETnWwY4Tpc44h[XO|YYm= NXPnXVd[OTBizszN Mk\EOEBp NV\JVGJkUW6lcnXhd4UhcW5iQV3QT4FteGijIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCKZYDHNkBk\WyuczDheEAyOCC3TTDh[pRmeiB2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYOgdoVt[XSrdnWgeI8hfW62cnXheIVlKGOxboTyc4w> MVqyN|A2QDFyNx?=
HepG2 cells NWfQTFVITnWwY4Tpc44h[XO|YYm= M{Lx[|ExKM7:TR?= MUG0JIg> MorHTY5kemWjc3WgbY4hfG:2YXygRW1RU2GucHjhJIxmfmWuIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDFyIIXNJIFnfGW{IESgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpd{Bz\WyjdHn2[UB1dyC3boTy[YF1\WRiY3;ueJJwdA>? NYfUPWFROjNyNUixNFc>
HepG2 cells MV\GeY5kfGmxbjDhd5NigQ>? M3TFTVIxKM7:TR?= MUiyOEBpenN? NF:1T3BKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KG2xcoDoc4xw\2mlYXygZ4hidmenczDheEAzOCC3TTDh[pRmeiB{NDDodpMhfXOrbnegTI9m[2i|dDCzN|I2QCC|dHHpcolv\yCkeTDmcJVwemW|Y3XuZ4UhdWmlcn;zZ49xcWNiYX7hcJl{cXN? NVm3b2RYOjNzOEKwPFg>
HT-29 cells MXTDfZRwfG:6aXPpeJkh[XO|YYm= NEKzdFk1QCCqcoO= MkfzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME24MlQ2KM7:TR?= NVnPTGh[OjNzOEKwPFg>
HepG2 cells MVHDfZRwfG:6aXPpeJkh[XO|YYm= MkLINlQhcHK| NUPqSJY1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOS5{MjFOwG0> NFj1Z4ozOzF6MkC4PC=>
HepG2 cells MnPXR5l1d3SxeHnjbZR6KGG|c3H5 MojIOFghcHK| M{G4N2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9PE4{OiEQvF2= M3jCblI{OTh{MEi4

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 40 mg/mL (107.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
3mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.81
Formula

C20H18NO4.Cl

CAS No. 633-65-8
Storage powder
in solvent
Synonyms N/A
Smiles COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03281096 Recruiting Drug: Berberine hydrochloride|Drug: Placebo Colorectal Adenomas xiaohua li|Xijing Hospital of Digestive Diseases August 29 2017 Phase 2|Phase 3
NCT02806999 Unknown status Drug: Berberine; Insulin|Drug: Insulin Hyperglycemia Guangdong Provincial People''s Hospital July 2016 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID