Neohesperidin

Synonyms: NSC 31048

Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent.

Neohesperidin Chemical Structure

Neohesperidin Chemical Structure

CAS: 13241-33-3

Selleck's Neohesperidin has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.63%
99.63

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Biological Activity

Description Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent.
In vitro
In vitro

Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent. Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. Neohesperidin (50 mg/kg) significantly inhibits HCl/ethanol-induced gastric lesions, and increases the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreases the volume of gastric secretion and gastric acid output, and increases the pH. [1] In addition, Neohesperidin inhibits the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukaemia cells with IC50 of 0.17, 0.17 and 0.12 mM, respectively. [2]

Chemical Information & Solubility

Molecular Weight 610.56 Formula

C28H34O15

CAS No. 13241-33-3 SDF Download Neohesperidin SDF
Smiles CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)CO)O)O)O)O)O
Storage (From the date of receipt) 3 years -20°C powder (seal)

In vitro
Batch:

DMSO : 100 mg/mL ( (163.78 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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