17-Hydroxyprogesterone

Catalog No.S4507

For research use only.

17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

17-Hydroxyprogesterone Chemical Structure

CAS No. 68-96-2

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Biological Activity

Description 17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
In vitro

17α-OHP is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison[1]. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.

In vivo 17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown)[3].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Male Panulirus polyphagus
  • Dosages: 0.01, 0.1 μg/g
  • Administration: Injection laterally to fifth abdominal segment
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 66 mg/mL
(199.72 mM)
Ethanol 66 mg/mL
(199.72 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 330.46
Formula

C21H30O3

CAS No. 68-96-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)C1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05063994 Not yet recruiting Drug: Chronocort|Drug: Cortef Congenital Adrenal Hyperplasia Diurnal Limited November 2021 Phase 3
NCT04783181 Recruiting Biological: AAV BBP-631 Congenital Adrenal Hyperplasia Adrenas Therapeutics Inc July 1 2021 Phase 1|Phase 2
NCT04806451 Recruiting Drug: Crinecerfont|Drug: Placebo Congenital Adrenal Hyperplasia Neurocrine Biosciences June 24 2021 Phase 3
NCT04890444 Not yet recruiting -- Cushing Syndrome|Aldosteronism|Hypoadrenalism|Congenital Adrenal Hyperplasia|Adrenal Adenoma|Adrenal Incidentaloma|Adrenal Carcinoma|Pheochromocytoma Shanghai Jiao Tong University School of Medicine June 1 2021 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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