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17-Hydroxyprogesterone

Name: 17-Hydroxyprogesterone
Brand: Selleck Chemicals
SKU: S4507
Rating: 5 (1 reviews)

Catalog No.S4507 Purity: 99.94%

17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

17-Hydroxyprogesterone Chemical Structure

CAS: 68-96-2

Purity & Quality Control

Batch: S450701 DMSO] 66 mg/mL] false] Ethanol] 66 mg/mL] false] Water] Insoluble] false Purity: 99.94%

99.94

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Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description	17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

In vitro
In vitro	17α-OHP is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison^[1]. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.

In Vivo
In vivo	17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown)^[3].
Animal Research	Animal Models	Male Panulirus polyphagus
	Dosages	0.01, 0.1 μg/g
	Administration	Injection laterally to fifth abdominal segment

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05907291	Recruiting	Congenital Adrenal Hyperplasia\|Classic Congenital Adrenal Hyperplasia	Crinetics Pharmaceuticals Inc.	July 3 2023	Phase 2
NCT05669950	Recruiting	Congenital Adrenal Hyperplasia	H. Lundbeck A/S	December 19 2022	Phase 1
NCT05299554	Enrolling by invitation	Congenital Adrenal Hyperplasia	Diurnal Limited	April 1 2022	Phase 3
NCT05272657	Not yet recruiting	Polycystic Ovary Syndrome (PCOS)	Federal State Budgetary Institution V. A. Almazov Federal North-West Medical Research Centre of the Ministry of Health	March 30 2022	Not Applicable
NCT05063994	Active not recruiting	Congenital Adrenal Hyperplasia	Diurnal Limited	December 13 2021	Phase 3

References

Chemical Information & Solubility

Molecular Weight	330.46	Formula	C₂₁H₃₀O₃
CAS No.	68-96-2	SDF	Download 17-Hydroxyprogesterone SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 66 mg/mL ( (199.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 66 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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