Desoxyrhaponticin

Catalog No.S3300 Synonyms: DC, DES

For research use only.

Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.

Desoxyrhaponticin Chemical Structure

CAS No. 30197-14-9

Selleck's Desoxyrhaponticin has been cited by 1 Publication

Purity & Quality Control

Choose Selective Fatty Acid Synthase Inhibitors

Biological Activity

Description Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Targets
FAS/FASN [1]
()
glucose [2]
(in rat everted gut sleeves)
glucose [2]
(in rabbit intestinal membrane vesicles)
30.9 μM 148.3 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(247.27 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.41
Formula

C21H24O8

CAS No. 30197-14-9
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05086757 Not yet recruiting Behavioral: TRRP|Behavioral: Enhanced Usual Care Traumatic Injury|Technology|Posttraumatic Stress Disorder|Adolescents Medical University of South Carolina|Children''s of Alabama|Boston Children''s Hospital|Prisma Health-Upstate|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) July 1 2022 Not Applicable
NCT04898491 Not yet recruiting Other: Pain assessment using a behavioral scale Pain|Brain Injuries|Behavior Candelas Lopez Lopez|Instituto de Salud Carlos III|Hospital Universitario 12 de Octubre March 1 2022 --
NCT04417777 Not yet recruiting Genetic: Blood Test Idiopathic Bronchiectasis Centre Hospitalier Intercommunal Creteil January 1 2022 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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