Desoxyrhaponticin

Catalog No.S3300 Synonyms: DC, DES

For research use only.

Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.

Desoxyrhaponticin Chemical Structure

CAS No. 30197-14-9

Selleck's Desoxyrhaponticin has been cited by 1 Publication

Purity & Quality Control

Choose Selective Fatty Acid Synthase Inhibitors

Biological Activity

Description Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Targets
FAS/FASN [1] glucose [2]
(in rat everted gut sleeves)
glucose [2]
(in rabbit intestinal membrane vesicles)
30.9 μM 148.3 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 404.41
Formula

C21H24O8

CAS No. 30197-14-9
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04231058 Not yet recruiting Device: TENS and pulmonary rehabilitation Dyspnea Azienda USL Toscana Nord Ovest|Auxilium Vitae Volterra October 1 2022 Not Applicable
NCT04827108 Not yet recruiting Other: PeNAT validation Cancer|Child|Nausea|Vomiting The Hong Kong Polytechnic University September 1 2022 --
NCT05316948 Not yet recruiting Other: self-questionnaire Psychiatric Disorder|Adolescent Behavior|Mental Health Issue Fondation Santé des Étudiants de France September 2022 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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