Home Metabolism Fatty Acid Synthase inhibitor - Carbohydrate Metabolism inhibitor - Apoptosis related activator Desoxyrhaponticin For research use only.

Desoxyrhaponticin

Synonyms: DC, DES

Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.

Desoxyrhaponticin Chemical Structure

Desoxyrhaponticin Chemical Structure

CAS: 30197-14-9

Selleck's Desoxyrhaponticin has been cited by 1 publication

Purity & Quality Control

Batch: S330001 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.88%
99.88

Desoxyrhaponticin Related Products

Choose Selective Fatty Acid Synthase Inhibitors

Biological Activity

Description Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Targets
FAS/FASN [1] glucose [2]
(in rat everted gut sleeves)		 glucose [2]
(in rabbit intestinal membrane vesicles)
30.9 μM 148.3 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04231058 Suspended
Dyspnea
Azienda USL Toscana Nord Ovest|Auxilium Vitae Volterra
 May 1 2024 Not Applicable
NCT06127407 Not yet recruiting
Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation Untreated or Previously Treated With 1 Systemic Treatment Regimen
Servier Bio-Innovation LLC|Institut de Recherches Internationales Servier|Servier
 April 1 2024 Phase 3
NCT06193382 Not yet recruiting
Traumatic Brain Injury|Disruptive Behavior
University of Miami
 March 1 2024 Not Applicable

Chemical Information & Solubility

Molecular Weight 404.41 Formula

C21H24O8
CAS No. 30197-14-9 SDF --
Smiles COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O)OC3OC(CO)C(O)C(O)C3O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (247.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Desoxyrhaponticin | Desoxyrhaponticin supplier | purchase Desoxyrhaponticin | Desoxyrhaponticin cost | Desoxyrhaponticin manufacturer | order Desoxyrhaponticin | Desoxyrhaponticin distributor