L-Quebrachitol

For research use only.

Catalog No.S3223 Synonyms: L-QCT

L-Quebrachitol Chemical Structure

CAS No. 642-38-6

L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.

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Biological Activity

Description L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
Targets
BMP-2 [1]
()
Runx2 [1]
()
MAPK [1]
()
Wnt/β-catenin [1]
()
NF-κB [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (514.98 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 194.18
Formula

C7H14O6

CAS No. 642-38-6
Storage powder
in solvent
Synonyms L-QCT

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID