Home Cell Cycle TGF-beta/Smad activator - RUNX activator - Wnt/beta-catenin activator - NF-κB inhibitor L-Quebrachitol For research use only.

L-Quebrachitol

Synonyms: L-QCT

L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.

L-Quebrachitol Chemical Structure

L-Quebrachitol Chemical Structure

CAS: 642-38-6

Purity & Quality Control

Batch: Purity: 100.00%
100.00

L-Quebrachitol Related Products

Signaling Pathway

TGF-beta/Smad Signaling Pathways

TGF-beta/Smad Signaling Pathway

Choose Selective TGF-beta/Smad Inhibitors

Biological Activity

Description L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
Targets
BMP-2 [1] Runx2 [1] MAPK [1] Wnt/β-catenin [1] NF-κB [1]

Chemical Information & Solubility

Molecular Weight 194.18 Formula

C7H14O6
CAS No. 642-38-6 SDF --
Smiles COC1C(O)C(O)C(O)C(O)C1O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 39 mg/mL ( (200.84 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 39 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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