4-Methylesculetin

Catalog No.S4966

For research use only.

4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.

4-Methylesculetin Chemical Structure

CAS No. 529-84-0

Purity & Quality Control

Choose Selective Peroxidases Inhibitors

Biological Activity

Description 4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
Targets
MPO [3]
()
IL-6 [3]
()
In vitro

ME inhibited hyaluronan (HA) synthesis by human pancreatic cancer cells and weakened their extracellular matrix. It inhibits the adhesion and invasion of cancer cells[1].

In vivo

ME showed a marked inhibitory effect on the tumor growth of pancreatic cancer in comparison with untreated controls[1]. 4-methylesculetin treatments prevent colonic damage induced by trinitrobenzenesulphonic acid (TNBS) in rats. This effect can be attributed to its antioxidant and anti-inflammatory properties[2].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 38 mg/mL
(197.74 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 192.17
Formula

C10H8O4

CAS No. 529-84-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=O)OC2=CC(=C(C=C12)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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