Indole-3-carbinol

Catalog No.S2313

Indole-3-carbinol Chemical Structure

Molecular Weight(MW): 147.18

Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
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  • CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Indole-3-carbinol purchased from Selleck.

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Biological Activity

Description Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.

Protocol

References

Solubility (25°C)

In vitro DMSO 29 mg/mL (197.03 mM)
Ethanol 29 mg/mL (197.03 mM)
Water 7 mg/mL (47.56 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 147.18
Formula

C9H9NO

CAS No. 700-06-1
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03687073 Recruiting Smoking Masonic Cancer Center University of Minnesota November 29 2018 Phase 1
NCT03687073 Recruiting Smoking Masonic Cancer Center University of Minnesota November 29 2018 Phase 1
NCT00988845 Terminated Obesity University of Wisconsin Madison September 2009 Phase 2
NCT00988845 Terminated Obesity University of Wisconsin Madison September 2009 Phase 2
NCT00607932 Completed Prostate Cancer Vanderbilt University|National Cancer Institute (NCI) March 2005 Not Applicable
NCT00607932 Completed Prostate Cancer Vanderbilt University|National Cancer Institute (NCI) March 2005 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID