Quercitrin

Catalog No.S3824 Synonyms: 3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine

Quercitrin Chemical Structure

Molecular Weight(MW): 448.38

Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.

Size Price Stock Quantity  
USD 97 In stock
USD 207 In stock
USD 570 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
In vitro

Quercitrin ameliorates cytokine-impaired viability of RINm5F cells and improves Glucose-stimulated insulin secretion in cytokine-treated RINm5F cells. It also reduces production of cellular ROS from cytokines and restrains the enhancement of NO production caused by cytokines in RINm5F cells via inhibition of iNOS expression[1].

In vivo Quercitrin significantly suppresses the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduces tissue plasminogen activator (t-PA) activity, enhances the antioxidant enzyme activities and abrogates cytochrome P450 2E1 (CYP2E1) induction in mouse brains. Quercitrin also prevents CCl4 induced cerebral function disorders associated with its ability to inhibit the activities of monoamine oxidase (MAO), acetylcholine esterase (AChE) and the N-methyl-D-aspartate receptor 2B subunit (NR2B). Quercitrin is known to have biological effects such as anti-oxidative, anti-inflammatory, and anti-apoptosis effects and it might be a more potent antioxidant and a neuroprotective agent than quercetin due to its high bioavailability in the digestive track. Quercitrin significantly reduces acute systemic inflammation in LPS-induced models as well as attenuates inflammation in the livers of mice. Quercitrin could also reduce inflammation and apoptosis in cytokine-induced models. In streptozotocin (STZ)-induced diabetic models, quercitrin displays organ protective properties in the pancreas, liver and kidney by improving the antioxidant status[2].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: The insulin-secreting cell line RINm5F
  • Concentrations: 0, 5, 10 and 20 μM
  • Incubation Time: 2 h
  • Method: Cells are cultured in DMEM with 10% FBS, 100 U/ml penicillin, 100 μg/ml streptomycin, 2 mmol/l in a humidified atmosphere (5% CO2, 37°C). After starvation for 24 h, cells are treated with quercetin or quercitrin (0, 5, 10 and 20 μM) for 2 h, then co-incubated with TNF-α (10 ng/ml), IL-1β (5 ng/ml) and IFN-γ (1,000 U/ml) for 24 h.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male ICR mice
  • Formulation: 0.5% carboxymethylcellulose sodium
  • Dosages: 50 and 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 89 mg/mL (198.49 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 448.38
Formula

C21H20O11

CAS No. 522-12-3
Storage powder
in solvent
Synonyms 3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Quercitrin | Quercitrin supplier | purchase Quercitrin | Quercitrin cost | Quercitrin manufacturer | order Quercitrin | Quercitrin distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID