Home Neuronal Signaling Other chemical Militarine

research use only

Militarine

Cat.No.E0247

Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect.
Militarine Chemical Structure

Chemical Structure

Molecular Weight: 726.72

Jump to

Quality Control

Batch: E024701 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.79%
99.79

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (137.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 726.72 Formula

C34H46O17

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 58139-23-4 -- Storage of Stock Solutions

Mechanism of Action

In vitro

Militarine remarkably decreases in IL-6, TNF-α, cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β) mRNA levels, phospho-IκB kinase β/IκB kinase β (p-IKKβ/IKKβ), phospho-nuclear factor of kappa B p65/nuclear factor of kappa B p65 (p-NF-κBp65/NF-κBp65) and COX-2 proteins, concomitant with a significant increase of expression of inhibitor of NF-κB (IκBα) protein in PM 2.5-exposed human lung alveolar epithelial A549 cells.
In vivo

Militarine promotes rehabilitation of white matter, and increases levels of myelin basic protein (MBP), also markedly suppresses loss of CNPase-positive oligodendrocytes in rats with chronic cerebral hypoperfusion.
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.