Home Neuronal Signaling Other chemical Militarine For research use only.

Militarine

Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect.

Militarine Chemical Structure

Militarine Chemical Structure

CAS: 58139-23-4

Purity & Quality Control

Batch: E024701 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.79%
99.79

Militarine Related Products

Biological Activity

Description Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect.
In vitro
In vitro

Militarine remarkably decreases in IL-6, TNF-α, cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β) mRNA levels, phospho-IκB kinase β/IκB kinase β (p-IKKβ/IKKβ), phospho-nuclear factor of kappa B p65/nuclear factor of kappa B p65 (p-NF-κBp65/NF-κBp65) and COX-2 proteins, concomitant with a significant increase of expression of inhibitor of NF-κB (IκBα) protein in PM 2.5-exposed human lung alveolar epithelial A549 cells.[2]
Cell Research Cell lines PM 2.5-exposed human lung alveolar epithelial A549 cells
Concentrations 1.25, 2.5, 5, 10 μg/ml
Incubation Time 2 h
Method

Cells are pretreated with coelonin (2.5, 5, 10, 20 μg/ml) or militarine (1.25, 2.5, 5, 10 μg/ml) for 2 h, followed by stimulation with PM2.5 (250 μg/ml) for 18 h. After treatment, the culture medium is centrifuged at 16,099 g for 10 min at 4℃ to separate the supernatant fraction. IL-6 and TNF-α levels are measured using the enzyme-linked immunosorbent assay according to the manufacturer s instructions.
In Vivo
In vivo

Militarine promotes rehabilitation of white matter, and increases levels of myelin basic protein (MBP), also markedly suppresses loss of CNPase-positive oligodendrocytes in rats with chronic cerebral hypoperfusion.[1]

Chemical Information & Solubility

Molecular Weight 726.72 Formula

C34H46O17
CAS No. 58139-23-4 SDF --
Smiles CC(C)CC(O)(CC(=O)OCC1=CC=C(OC2OC(CO)C(O)C(O)C2O)C=C1)C(=O)OCC3=CC=C(OC4OC(CO)C(O)C(O)C4O)C=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (137.6 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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