Home Apoptosis OXPHOS inhibitor - Dehydrogenase inhibitor 4-Methyl-2-oxovaleric acid For research use only.

4-Methyl-2-oxovaleric acid

Synonyms: Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate

4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity.

4-Methyl-2-oxovaleric acid Chemical Structure

4-Methyl-2-oxovaleric acid Chemical Structure

CAS: 816-66-0

Purity & Quality Control

Batch: S298701 Purity: 99.31%
99.31

4-Methyl-2-oxovaleric acid Related Products

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Biological Activity

Description 4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity.
Targets
OGDC [1] OXPHOS [1]

Chemical Information & Solubility

Molecular Weight 130.14 Formula

C6H10O3
CAS No. 816-66-0 SDF --
Density 1.055 g/mL
Smiles CC(C)CC(=O)C(O)=O
Storage (From the date of receipt) 2 years -20°C liquid

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