3,5-diiodo-L-thyronine (3,5-T2)

Catalog No.S6474 Synonyms: NSC 90469

For research use only.

3,5-diiodo-L-thyronine (3,5-T2, NSC 90469) is an endogenous metabolite of thyroid hormones. 3,5-Diiodo-l-thyronine has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis.

3,5-diiodo-L-thyronine (3,5-T2) Chemical Structure

CAS No. 1041-01-6

Purity & Quality Control

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Biological Activity

Description 3,5-diiodo-L-thyronine (3,5-T2, NSC 90469) is an endogenous metabolite of thyroid hormones. 3,5-Diiodo-l-thyronine has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 525.08
Formula

C15H13I2NO4

CAS No. 1041-01-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(C(=O)O)N)I

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04370366 Not yet recruiting -- Meniere Disease King''s College Hospital NHS Trust|King''s College London|Guy''s and St Thomas'' NHS Foundation Trust July 2022 --
NCT04134910 Not yet recruiting Procedure: Physical Therapy Back Pain|Intervertebral Disc Degeneration VA Office of Research and Development May 2 2022 Not Applicable
NCT05174546 Not yet recruiting Diagnostic Test: T2 magnetic resonance Febrile Neutropenia The University of Queensland April 1 2022 --
NCT04743791 Not yet recruiting Drug: Dupilumab|Other: Placebo Asthma Sally E. Wenzel MD|University of Pittsburgh March 1 2022 Phase 4
NCT05184322 Not yet recruiting Drug: XW004|Drug: T2026|Drug: Placebo Obesity|Type 2 Diabetes Mellitus Sciwind Biosciences APAC CO Pty. Ltd.|Hangzhou Sciwind Biosciences Co. Ltd. February 1 2022 Phase 1
NCT05090033 Not yet recruiting Other: ofatumumab Relapsing Multiple Sclerosis Novartis Pharmaceuticals|Novartis February 10 2022 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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