Veratramine

Catalog No.S3911 Synonyms: NSC 17821, NSC 23880

For research use only.

Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.

Veratramine Chemical Structure

CAS No. 60-70-8

Purity & Quality Control

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Biological Activity

Description Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.
In vitro

Veratramine antagonizes the Na+ channel-gating mechanism of ceveratrum alkaloids by blocking Na+ channels. Veratramine also shows serotonin (5-HT) agonist activity, acting on presynaptic 5-HT neurons[1].

In vivo The administration of vertatramine induces generalized tremors, myoclonus, hindlimb abduction, backward gait, and Straub tail, similar to the 5-HT syndrome in mice. Veratramine causes bradycardia and periodic rhythm in the sinoatrial node of the guinea pig. The lethal dose 50% (LD50) of VAM for mice is 15.9 mg/kg with intragastrical administration [1]. Vertatramine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. As a major Veratrum alkaloid, veratramine (VAM) is significantly effective against hypertension by reflective inhibition of vasomotor center and tumor as an antagonist of the hedgehog signaling. Vertatramine may exert neurotoxic effects[2].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Kunming mice
  • Dosages: 0.56 to 2.24 mg/kg
  • Administration: oral ingestion

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 409.60
Formula

C27H39NO2

CAS No. 60-70-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CC(C(NC1)C(C)C2=C(C3=C(C=C2)C4CC=C5CC(CCC5(C4C3)C)O)C)O

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