Home Transmembrane Transporters Sodium Channel antagonist Veratramine

research use only

Veratramine Sodium Channel antagonist

Cat.No.S3911

Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.
Veratramine Sodium Channel antagonist Chemical Structure

Chemical Structure

Molecular Weight: 409.60

Jump to

Quality Control

Batch: S391101 DMSO]63 mg/mL]false]]]false]]]false Purity: 99.97%
99.97

Solubility

In vitro
Batch:

DMSO : 63 mg/mL (153.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 409.60 Formula

C27H39NO2

 Storage (From the date of receipt)
CAS No. 60-70-8 Download SDF Storage of Stock Solutions

Synonyms NSC 17821, NSC 23880 Smiles CC1CC(C(NC1)C(C)C2=C(C3=C(C=C2)C4CC=C5CC(CCC5(C4C3)C)O)C)O

Mechanism of Action

In vitro
Veratramine antagonizes the Na+ channel-gating mechanism of ceveratrum alkaloids by blocking Na+ channels. This compound also shows serotonin (5-HT) agonist activity, acting on presynaptic 5-HT neurons.
In vivo
The administration of vertatramine induces generalized tremors, myoclonus, hindlimb abduction, backward gait, and Straub tail, similar to the 5-HT syndrome in mice. This compound causes bradycardia and periodic rhythm in the sinoatrial node of the guinea pig. The lethal dose 50% (LD50) of VAM for mice is 15.9 mg/kg with intragastrical administration . It causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. As a major Veratrum alkaloid, this chemical is significantly effective against hypertension by reflective inhibition of vasomotor center and tumor as an antagonist of the hedgehog signaling. It may exert neurotoxic effects.
References
  • [1] https://pubmed.ncbi.nlm.nih.gov/18771011/
  • [2] https://watermark.silverchair.com/bmu171.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAbAwggGsBgkqhkiG9w0BBwagggGdMIIBmQIBADCCAZIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMSXHtjn_ZivO0uYWqAgEQgIIBY2RxIqsIFVd0APwpkhvA46irFSnwuOwTRD5WPbWNjopRUBZZ_x0018_䲧畘Ỵ留

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map