Veratramine

Catalog No.S3911 Synonyms: NSC 17821, NSC 23880

Veratramine Chemical Structure

Molecular Weight(MW): 409.60

Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.

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Biological Activity

Description Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.
In vitro

Veratramine antagonizes the Na+ channel-gating mechanism of ceveratrum alkaloids by blocking Na+ channels. Veratramine also shows serotonin (5-HT) agonist activity, acting on presynaptic 5-HT neurons[1].

In vivo The administration of vertatramine induces generalized tremors, myoclonus, hindlimb abduction, backward gait, and Straub tail, similar to the 5-HT syndrome in mice. Veratramine causes bradycardia and periodic rhythm in the sinoatrial node of the guinea pig. The lethal dose 50% (LD50) of VAM for mice is 15.9 mg/kg with intragastrical administration [1]. Vertatramine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. As a major Veratrum alkaloid, veratramine (VAM) is significantly effective against hypertension by reflective inhibition of vasomotor center and tumor as an antagonist of the hedgehog signaling. Vertatramine may exert neurotoxic effects[2].

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Kunming mice
  • Formulation: Tween-80, 0.2% in distilled water
  • Dosages: 0.56 to 2.24 mg/kg
  • Administration: oral ingestion
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 63 mg/mL (153.8 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 409.60
Formula

C27H39NO2

CAS No. 60-70-8
Storage powder
in solvent
Synonyms NSC 17821, NSC 23880

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