Bornyl acetate

Catalog No.S3893 Synonyms: Isobornyl acetate, Bornyl acetic ether, 2-Camphanol acetate

For research use only.

Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.

Bornyl acetate Chemical Structure

CAS No. 76-49-3

Purity & Quality Control

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Biological Activity

Description Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
In vitro

Bornyl acetate induces dose-dependent growth inhibitory effects on human gastric cancer cells in vitro. Bornyl acetate potentiates the anticancer activity of 5-FU in human gastric cancer (SGC-7901) cells by inducing apoptosis, DNA fragmentation as well as G2/M cell cycle arrest[2].

In vivo Bornyl acetate downregulates the levels of proinflammatory cytokines in vitro and in vivo; reduces the number of total cells, neutrophils, and macrophages in BALF; attenuates the histologic alterations in the lung; decreases the wet-to-dry weight ratio in BALF; and suppresses NF-kappa-B inhibitor alpha, extracellular regulated protein kinases, c-JunN-terminal kinase, p38 mitogen-activated protein kinase activation[1].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: RAW 264.7 cells.
  • Concentrations: 0-500 μg/mL
  • Incubation Time: 18 h
  • Method: RAW 264.7 cells are cultured with bornyl acetate (0-500 μg/mL) in the absence or presence of LPS (1 mg/L) for 18 h. Cell viability is assessed by MTT reduction assays.
  • (Only for Reference)
Animal Research:[1]
  • Animal Models: BALB/c mice
  • Dosages: 25, 50, and 100mg/kg
  • Administration: i.p.
  • (Only for Reference)

Chemical Information

Molecular Weight 196.29
Formula

C12H20O2

Density 0.985 g/mL at 25 °C
CAS No. 76-49-3
Storage 2 years -20°C liquid
Smiles CC(=O)OC1CC2CCC1(C2(C)C)C

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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