Home Metabolism ATP-citrate lyase inhibitor 2-Furoic acid

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2-Furoic acid ATP-citrate lyase inhibitor

Cat.No.S4864

2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent.
2-Furoic acid ATP-citrate lyase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 112.08

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S486401 DMSO]22 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 112.08 Formula

C5H4O3

 Storage (From the date of receipt)
CAS No. 88-14-2 -- Storage of Stock Solutions

Synonyms 2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid Smiles C1=COC(=C1)C(=O)O

Solubility

In vitro
Batch:

DMSO : 22 mg/mL ( (196.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01597401 Completed
Sickle Cell Disease
Baxalta now part of Shire|SAIC-Frederick Inc.|Therapeutics for Rare and Neglected Diseases (TRND)|QS Pharma|National Chung Cheng University|Infrared Imaging and Thermometry Unit Biomedical Engineering and Physical Science Shared Resource (NIBIB)|ClinPharm Consulting LLC|Ricerca Biosciences LLC|National Heart Lung and Blood Institute (NHLBI)|Cato Research|Takeda
 May 12 2012 Phase 1

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