9-amino-CPT (9-Aminocamptothecin)

For research use only.

Catalog No.S2653 Synonyms: 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin

9-amino-CPT (9-Aminocamptothecin) Chemical Structure

CAS No. 91421-43-1

9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.

Purity & Quality Control

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Biological Activity

Description 9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.
Targets
Topo I [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 25 mg/mL (68.8 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 363.37
Formula
C20H17N3O4
CAS No. 91421-43-1
Storage powder
in solvent
Synonyms 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04909489 Recruiting Other: cross-sectional study without intervention Traditional Chinese Medicine|Dyslipidemias|Syndrome Dongzhimen Hospital Beijing April 21 2021 --
NCT03978624 Recruiting Drug: Pembrolizumab|Drug: Entinostat Bladder Cancer UNC Lineberger Comprehensive Cancer Center September 23 2020 Phase 2
NCT00003154 Completed Drug: aminocamptothecin colloidal dispersion Lung Cancer Case Comprehensive Cancer Center|National Cancer Institute (NCI) January 1998 Phase 2
NCT00002745 Completed Drug: aminocamptothecin Lymphoma National Cancer Institute (NCI) April 1996 Phase 2
NCT00251368 Completed Drug: 9-Aminocamptothecin (9-AC) Leukemia Myelocytic Acute|Acute Lymphocytic Leukemia Dana-Farber Cancer Institute|Brigham and Women''s Hospital|Beth Israel Deaconess Medical Center|Massachusetts General Hospital January 1995 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID