9-amino-CPT (9-Aminocamptothecin)

Catalog No.S2653 Synonyms: 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin

For research use only.

9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.

9-amino-CPT (9-Aminocamptothecin) Chemical Structure

CAS No. 91421-43-1

Purity & Quality Control

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Biological Activity

Description 9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.
Targets
Topo I [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 363.37
Formula
C20H17N3O4
CAS No. 91421-43-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04909489 Recruiting Other: cross-sectional study without intervention Traditional Chinese Medicine|Dyslipidemias|Syndrome Dongzhimen Hospital Beijing April 21 2021 --
NCT03978624 Recruiting Drug: Pembrolizumab|Drug: Entinostat Bladder Cancer UNC Lineberger Comprehensive Cancer Center September 23 2020 Phase 2
NCT00003154 Completed Drug: aminocamptothecin colloidal dispersion Lung Cancer Case Comprehensive Cancer Center|National Cancer Institute (NCI) January 1998 Phase 2
NCT00002745 Completed Drug: aminocamptothecin Lymphoma National Cancer Institute (NCI) April 1996 Phase 2
NCT00251368 Completed Drug: 9-Aminocamptothecin (9-AC) Leukemia Myelocytic Acute|Acute Lymphocytic Leukemia Dana-Farber Cancer Institute|Brigham and Women''s Hospital|Beth Israel Deaconess Medical Center|Massachusetts General Hospital January 1995 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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