L-Thyroxine sodium salt pentahydrate

Synonyms: Sodium Levothyroxine pentahydrate, L-T4 sodium pentahydrate

L-Thyroxine (Levothyroxine, L-T4) sodium salt pentahydrate is a synthetic T4 hormone used to counterbalance hypothyroidism.

L-Thyroxine sodium salt pentahydrate Chemical Structure

L-Thyroxine sodium salt pentahydrate Chemical Structure

CAS: 6106-07-6

Purity & Quality Control

Batch: S519301 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.57%
99.57

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Biological Activity

Description L-Thyroxine (Levothyroxine, L-T4) sodium salt pentahydrate is a synthetic T4 hormone used to counterbalance hypothyroidism.
In Vivo
In vivo

Administering L-thyroxine (L-T4) to Slc26a7 and Slc26a4 double-deficient mice tends to improve their growth to some extent.[2]

Animal Research Animal Models Slc26a7 and Slc26a4 double-deficient mice
Dosages 0.39 mg/L
Administration o.g.

Chemical Information & Solubility

Molecular Weight 888.93 Formula

C15H20I4NNaO9

CAS No. 6106-07-6 SDF --
Smiles O.O.O.O.O.[Na+].NC(CC1=CC(=C(OC2=CC(=C(O)C(=C2)I)I)C(=C1)I)I)C([O-])=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (112.49 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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