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Citicoline

Synonyms: CDP-choline, cytidine 5'-diphosphocholine

Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis.

Citicoline Chemical Structure

Citicoline Chemical Structure

CAS: 987-78-0

Purity & Quality Control

Batch: S536201 Water] 97 mg/mL] false] DMSO] Insoluble] false] ] ] false Purity: 99.96%
99.96

Citicoline Related Products

Biological Activity

Description Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05881135 Recruiting
COVID-19
Ohio State University
 June 6 2023 Phase 1|Phase 2
NCT05200208 Recruiting
Alzheimer Disease
Emory University|National Institute on Aging (NIA)|Goizueta Alzheimer''s Disease Research Center (ADRC)
 July 27 2022 Not Applicable
NCT05315206 Recruiting
Primary Open Angle Glaucoma
Fondazione G.B. Bietti IRCCS
 January 25 2022 Not Applicable
NCT05000190 Completed
Attention
PepsiCo Global R&D
 September 13 2021 Not Applicable
NCT05154903 Recruiting
Acute Ischemic Stroke
Ain Shams University|Kafrelsheikh University
 July 22 2021 Phase 3
NCT04003090 Completed
Neurodegenerative Diseases
Istituto di Ricerca Neuroftalmologia S.r.l.|Fondazione G.B. Bietti IRCCS
 March 21 2018 Not Applicable

Chemical Information & Solubility

Molecular Weight 488.32 Formula

C14H26N4O11P2
CAS No. 987-78-0 SDF --
Smiles C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OCC1C(C(C(O1)N2C=CC(=NC2=O)N)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 97 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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