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Citicoline

Cat.No.S5362

Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis.
Citicoline Chemical Structure

Chemical Structure

Molecular Weight: 488.32

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Quality Control

Batch: S536201 Water]97 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 99.96%
99.96

Solubility

In vitro
Batch:

Water : 97 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 488.32 Formula

C14H26N4O11P2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 987-78-0 -- Storage of Stock Solutions

Synonyms CDP-choline, cytidine 5'-diphosphocholine SMILES C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OCC1C(C(C(O1)N2C=CC(=NC2=O)N)O)O

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Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2019-05-29)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03949049 RECRUITING
Neonatal Hypoxia
Sherief Abd-Elsalam
 2019-02-01 PHASE3
NCT03966170 RECRUITING
Pre-Term
Sherief Abd-Elsalam
 2019-05-01 PHASE3
NCT07804498 RECRUITING
Perioperative Delirium; Hip Fracture; Post-Operative Cognitive Decline in Older Adults
University of Milano Bicocca
 2026-06-03 PHASE2
NCT07322965 RECRUITING
Glaucoma; Primary Open Angle Glaucoma (POAG); Neuroprotection
Institut Catala de Retina
 2025-04-01
NCT07763145 NOT_YET_RECRUITING
Hypoxic Ischaemic Encephalopathy (HIE)
Khyber Girls Medical College
 2026-09-01
NCT05870111 ACTIVE_NOT_RECRUITING
Alcohol Use Disorder
Medical University of South Carolina
 2024-10-01 PHASE2

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