Citicoline

Catalog No.S5362 Synonyms: CDP-choline, cytidine 5'-diphosphocholine

For research use only.

Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis.

Citicoline Chemical Structure

CAS No. 987-78-0

Purity & Quality Control

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Biological Activity

Description Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis.

Protocol (from reference)

Solubility (25°C)

In vitro

Water 97 mg/mL
(198.64 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 488.32
Formula

C14H26N4O11P2

CAS No. 987-78-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OCC1C(C(C(O1)N2C=CC(=NC2=O)N)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05000190 Not yet recruiting Dietary Supplement: Active capsule|Other: Placebo capsule Attention PepsiCo Global R&D August 30 2021 Not Applicable
NCT05154903 Recruiting Drug: Citicoline 500 MG Acute Ischemic Stroke Ain Shams University|Kafrelsheikh University July 22 2021 Phase 3
NCT04003090 Completed Drug: Citicoline Neurodegenerative Diseases Istituto di Ricerca Neuroftalmologia S.r.l.|Fondazione G.B. Bietti IRCCS March 21 2018 Not Applicable
NCT04422743 Terminated Dietary Supplement: Citicoline 500 mg plus Homotaurine 50 mg Glaucoma IRCCS Policlinico S. Matteo January 25 2018 Not Applicable
NCT02823106 Withdrawn Drug: Verapamil and Citicoline|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky August 2016 Phase 1
NCT04009980 Completed Other: OMK2 group|Other: Placebo group Diabetic Retinopathy Fondazione G.B. Bietti IRCCS September 23 2015 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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