Lycorine

Catalog No.S3903 Synonyms: Galanthidine, Amarylline, Narcissine, Licorine, Belamarine

For research use only.

Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.

Lycorine Chemical Structure

CAS No. 476-28-8

Selleck's Lycorine has been cited by 1 Publication

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Biological Activity

Description Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.
In vitro

Lycorine can inhibit protein synthesis in eukaryotic cells and acetylcholinesterase activity. Lycorine could effectively arrest the cell cycle at the G2/M phase and induce apoptosis in HL-60 cells. It is able to block the KM3 cell cycle at G0/G1 phase through the down-regulation of both cyclin D1 and CDK4[2].

In vivo Lycorine, when tested in the human leukemia xenograft models, appears to exhibit anti-tumor activity in vivo. It prolongs the mean survival time of SCID leukemia xenograft models. Lycorine could alleviate the infiltration of tumor cells into tissues[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: Caki-1; ACHN; KPK-1 and Renca cell lines
  • Concentrations: 0, 0.5, 1, 5, and 10 μM
  • Incubation Time: 24, 48, 72, and 96 h
  • Method: The cell lines Caki-1; ACHN; KPK-1 and Renca are diluted in 96-well plates at a density of 1 × 103 and incubated with medium alone or serial dilutions of lycorine hydrochloride (0, 0.5, 1, 5, and 10 μM). Cell viability is monitored after 24, 48, 72, and 96 h. For each time point, the XTT labeling reagent and an electron coupling reagent is added to the culture. The cells are incubated for 4 h at 37°C and 5% CO2, and absorbance at 450–500 nm, with a reference wavelength at 650 nm, is recorded using a Bio-Rad microplate reader.
  • (Only for Reference)
Animal Research:[1]
  • Animal Models: C57BL/6 mice inoculated with Renca-Luc cells into the sub-renal capsule kidney and tail vein (orthotopic tumor and metastatic lung tumors model)
  • Dosages: 5 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 57 mg/mL
(198.39 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 287.31
Formula

C16H17NO4

CAS No. 476-28-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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