Oleic Acid

For research use only.

Catalog No.S4707 Synonyms: Oleate, 9-Octadecenoic Acid, Elaidoic acid

Oleic Acid Chemical Structure

Molecular Weight(MW): 282.46

Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.

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Biological Activity

Description Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
In vitro

Oleic acid treatment induces a marked increase in the proliferation of 786-O cells in a dose-dependent manner. It delays 786-O cell apoptosis. In 786‑O cells, ILK is upregulated by oleic acid treatment. Oleic acid activates G protein-coupled receptors and phosphorylates ERK1/2 to induce cancer cell proliferation in breast cancer[1]. Oleic acid(as low as 5 M) inhibits the stearic acid-induced increase in intercellular adhesion molecule-1 (ICAM-1) expression. Oleic acid is able to diminish endothelial cell activation, irrespective of the stimulus utilized, by suppressing the upregulation of adhesion molecules. It can protect Chinese hamster ovary cells from palmitate-induced lipotoxicity by promoting triglyceride synthesis within the cells[2].

In vivo Oleic acid inhibits in vivo Na/K-ATPase activity in the lungs and induced lung injury. 10 μM oleic acid induces lung edema and inflammation with cell influx, lipid body formation, and leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) production[3]. Oleic acid ameliorates amyloidosis in mouse models of Alzheimer's disease[4].

Protocol

Cell Research:

[1]

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  • Cell lines: Human RCC(renal cell carcinoma) cell line, 786-O.
  • Concentrations: 0.05, 0.1, 0.2 mmol/l
  • Incubation Time: 48 h
  • Method:

    Cells (2x103 cells/well) are seeded in 96-well microtitre plates and incubated for 24 h in 100 µl culture medium. Cells in the experimental group were then treated with 0.05, 0.1 or 0.2 mmol/l oleic acid for 48 h. MTT [20 µl (5 g/l)] is added to the cells which were then cultivated for a further 4 h. Following the removal of the supernatant fluid, 150 µl/well DMSO is added to the cells which are agitated for 15 min. Absorbance is measured at 490 nm by an ELISA reader.


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: male Swiss mice
  • Dosages: 2.5, 5.0 or 10.0 μmol
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 282.46
Formula

C18H34O2

Density 0.89 g/mL at 25 °C
CAS No. 112-80-1
Storage powder
in solvent
Synonyms Oleate, 9-Octadecenoic Acid, Elaidoic acid
Smiles CCCCCCCC\C=C/CCCCCCCC(O)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04053569 Active not recruiting Dietary Supplement: Table Grape supplement Metabolic Syndrome Protection Against Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis October 1 2019 Not Applicable
NCT03524742 Recruiting Other: Avocado-Mediterranean Diet|Other: Control-Group Diet Stroke Acute|Stroke Ischemic Clinica Alemana de Santiago|Comisión Nacional de Investigación Científica y Tecnológica August 16 2018 Not Applicable
NCT02863185 Unknown status Drug: Pitavastatin|Drug: Atorvastatin Chronic Kidney Disease Dong-A University May 2016 Phase 4
NCT02992548 Completed Drug: Pravastatin Chronic Kidney Disease Dong-A University September 2015 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID