Oleic Acid

Catalog No.S4707 Synonyms: Oleate, 9-Octadecenoic Acid, Elaidoic acid

For research use only.

Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid) is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.

Oleic Acid Chemical Structure

CAS No. 112-80-1

Selleck's Oleic Acid has been cited by 2 Publications

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Biological Activity

Description Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid) is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
In vitro

Oleic acid treatment induces a marked increase in the proliferation of 786-O cells in a dose-dependent manner. It delays 786-O cell apoptosis. In 786‑O cells, ILK is upregulated by oleic acid treatment. Oleic acid activates G protein-coupled receptors and phosphorylates ERK1/2 to induce cancer cell proliferation in breast cancer[1]. Oleic acid(as low as 5 M) inhibits the stearic acid-induced increase in intercellular adhesion molecule-1 (ICAM-1) expression. Oleic acid is able to diminish endothelial cell activation, irrespective of the stimulus utilized, by suppressing the upregulation of adhesion molecules. It can protect Chinese hamster ovary cells from palmitate-induced lipotoxicity by promoting triglyceride synthesis within the cells[2].

In vivo Oleic acid inhibits in vivo Na/K-ATPase activity in the lungs and induced lung injury. 10 μM oleic acid induces lung edema and inflammation with cell influx, lipid body formation, and leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) production[3]. Oleic acid ameliorates amyloidosis in mouse models of Alzheimer's disease[4].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Human RCC(renal cell carcinoma) cell line, 786-O.
  • Concentrations: 0.05, 0.1, 0.2 mmol/l
  • Incubation Time: 48 h
  • Method:

    Cells (2x103 cells/well) are seeded in 96-well microtitre plates and incubated for 24 h in 100 µl culture medium. Cells in the experimental group were then treated with 0.05, 0.1 or 0.2 mmol/l oleic acid for 48 h. MTT [20 µl (5 g/l)] is added to the cells which were then cultivated for a further 4 h. Following the removal of the supernatant fluid, 150 µl/well DMSO is added to the cells which are agitated for 15 min. Absorbance is measured at 490 nm by an ELISA reader.

Animal Research:

[3]

  • Animal Models: male Swiss mice
  • Dosages: 2.5, 5.0 or 10.0 μmol
  • Administration: i.v.

Chemical Information

Molecular Weight 282.46
Formula

C18H34O2

Density 0.89 g/mL at 25 °C
CAS No. 112-80-1
Storage 2 years -20°C liquid
Smiles CCCCCCCCC=CCCCCCCCC(=O)O

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04614233 Recruiting Dietary Supplement: RiduZone (90% OEA)|Other: Placebo Overweight and Obesity Yale University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) April 6 2021 Phase 4
NCT04053569 Active not recruiting Dietary Supplement: Table Grape supplement Metabolic Syndrome Protection Against Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis October 1 2019 Not Applicable
NCT04832217 Completed Other: Pyrenees´ Beef diet Body Weight Changes|Habits Diet|Habit Food|Life Change Events Universidad de Zaragoza January 20 2019 Not Applicable
NCT03524742 Recruiting Other: Avocado-Mediterranean Diet|Other: Control-Group Diet Stroke Acute|Stroke Ischemic Clinica Alemana de Santiago|Comisión Nacional de Investigación Científica y Tecnológica August 16 2018 Not Applicable
NCT02863185 Completed Drug: Pitavastatin|Drug: Atorvastatin Chronic Kidney Disease Dong-A University May 1 2016 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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