Resibufogenin

Catalog No.S3238 Synonyms: Bufogenin, Recibufogenin

For research use only.

Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.

Resibufogenin Chemical Structure

CAS No. 465-39-4

Purity & Quality Control

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Biological Activity

Description Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
Targets
RIP3 [1]
()
MLK [1]
()
ROS [1]
()
Caspase-3 [2]
()
Caspase-8 [2]
()
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Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(260.07 mM)


Chemical Information

Molecular Weight 384.51
Formula

C24H32O4

CAS No. 465-39-4
Storage 3 years -20°C powder
2 years -80°C in solvent

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