Abietic Acid

Catalog No.S5122 Synonyms: Sylvic acid, Abietate, L-Abietic acid, Rosin Acid

For research use only.

Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.

Abietic Acid Chemical Structure

CAS No. 514-10-3

Purity & Quality Control

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Biological Activity

Description Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
Targets
PPARγ [3] 5-lipoxygenase [1]
29.5 μM
In vitro

Abietic acid has anti-inflammatory effects by inhibiting expression of genes involved in inflammation such as those for tumor necrosis factor-a and cyclooxygenase 2 in lipopolysaccharide-induced macrophages. Abietic acid regulates PPARγ target gene expression in RAW 264.7 macrophages and 3T3L adipocytes. It can be used for regulating lipid metabolism and atherosclelosis[2]. Abietic acid is a PPARγ ligand and that its anti-in£ammatory effect is partly due to the activation of PPARγ in stimulated macrophages. In lipopolysaccharide (LPS)-stimulated macrophages, abietic acid suppresses production of prostaglandin E2 (PGE2) in vitro and in vivo[1].

In vivo Abietic acid has an antiobesity effect in mice mediated by the regulation of adipogenesis[2].

Protocol (from reference)

Cell Research:

[3]

  • Cell lines: CV1 cell
  • Concentrations: 0-100μM
  • Incubation Time: 24 h
  • Method:

    pM-hPPARγ, p4xUASg-tk-luc, pCMX-CBP and pRL-CMV are transfected into CV1 cells and then, 24 h after the transfection, the cells are treated with abietic acid at various concentrations for 24 h.

Animal Research:

[2]

  • Animal Models: Male C57BL/6J mice
  • Dosages: 20 mg/kg and 40 mg/kg
  • Administration: oral administration

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 302.45
Formula

C20H30O2

CAS No. 514-10-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C1=CC2=CCC3C(C2CC1)(CCCC3(C)C(=O)O)C

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