Home Metabolism Lipoxygenase inhibitor Abietic Acid For research use only.

Abietic Acid

Synonyms: Sylvic acid, Abietate, L-Abietic acid, Rosin Acid

Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.

Abietic Acid Chemical Structure

Abietic Acid Chemical Structure

CAS: 514-10-3

Purity & Quality Control

Batch: S512201 DMSO] 60 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Biological Activity

Description Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
Targets
PPARγ [3] 5-lipoxygenase [1]
29.5 μM
In vitro
In vitro Abietic acid has anti-inflammatory effects by inhibiting expression of genes involved in inflammation such as those for tumor necrosis factor-a and cyclooxygenase 2 in lipopolysaccharide-induced macrophages. Abietic acid regulates PPARγ target gene expression in RAW 264.7 macrophages and 3T3L adipocytes. It can be used for regulating lipid metabolism and atherosclelosis[2]. Abietic acid is a PPARγ ligand and that its anti-in£ammatory effect is partly due to the activation of PPARγ in stimulated macrophages. In lipopolysaccharide (LPS)-stimulated macrophages, abietic acid suppresses production of prostaglandin E2 (PGE2) in vitro and in vivo[1].
Cell Research Cell lines CV1 cell
Concentrations 0-100μM
Incubation Time 24 h
Method

pM-hPPARγ, p4xUASg-tk-luc, pCMX-CBP and pRL-CMV are transfected into CV1 cells and then, 24 h after the transfection, the cells are treated with abietic acid at various concentrations for 24 h.
In Vivo
In vivo Abietic acid has an antiobesity effect in mice mediated by the regulation of adipogenesis[2].
Animal Research Animal Models Male C57BL/6J mice
Dosages 20 mg/kg and 40 mg/kg
Administration oral administration

Chemical Information & Solubility

Molecular Weight 302.45 Formula

C20H30O2
CAS No. 514-10-3 SDF Download Abietic Acid SDF
Smiles CC(C)C1=CC2=CCC3C(C2CC1)(CCCC3(C)C(=O)O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 60 mg/mL ( (198.37 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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