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Abietic Acid Lipoxygenase inhibitor

Name: Abietic Acid
Brand: Selleck Chemicals
SKU: S5122
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S5122

Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.

Chemical Structure

Molecular Weight: 302.45

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S512201 DMSO]60 mg/mL]false]]]false]]]false Purity: 98%

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Chemical Information, Storage & Stability

Molecular Weight	302.45	Formula	C₂₀H₃₀O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	514-10-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Sylvic acid, Abietate, L-Abietic acid, Rosin Acid			Smiles	CC(C)C1=CC2=CCC3C(C2CC1)(CCCC3(C)C(=O)O)C

Solubility

In vitro
Batch:

DMSO : 60 mg/mL (198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	PPARγ ^[3] 5-lipoxygenase ^[1] 29.5 μM
In vitro	Abietic acid has anti-inflammatory effects by inhibiting expression of genes involved in inflammation such as those for tumor necrosis factor-a and cyclooxygenase 2 in lipopolysaccharide-induced macrophages. Abietic acid regulates PPARγ target gene expression in RAW 264.7 macrophages and 3T3L adipocytes. It can be used for regulating lipid metabolism and atherosclelosis^[2]. Abietic acid is a PPARγ ligand and that its anti-in£ammatory effect is partly due to the activation of PPARγ in stimulated macrophages. In lipopolysaccharide (LPS)-stimulated macrophages, abietic acid suppresses production of prostaglandin E2 (PGE2) in vitro and in vivo^[1].
In vivo	Abietic acid has an antiobesity effect in mice mediated by the regulation of adipogenesis^[2].
References	[1] https://pubmed.ncbi.nlm.nih.gov/11807975/ [2] https://pubmed.ncbi.nlm.nih.gov/21812648/ [3] https://pubmed.ncbi.nlm.nih.gov/12935909/

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