Abietic Acid

For research use only.

Catalog No.S5122 Synonyms: Sylvic acid, Abietate, L-Abietic acid, Rosin Acid

Abietic Acid Chemical Structure

Molecular Weight(MW): 302.45

Abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.

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Biological Activity

Description Abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
Targets
PPARγ [3]
()
5-lipoxygenase [1]
()
29.5 μM
In vitro

Abietic acid has anti-inflammatory effects by inhibiting expression of genes involved in inflammation such as those for tumor necrosis factor-a and cyclooxygenase 2 in lipopolysaccharide-induced macrophages. Abietic acid regulates PPARγ target gene expression in RAW 264.7 macrophages and 3T3L adipocytes. It can be used for regulating lipid metabolism and atherosclelosis[2]. Abietic acid is a PPARγ ligand and that its anti-in£ammatory effect is partly due to the activation of PPARγ in stimulated macrophages. In lipopolysaccharide (LPS)-stimulated macrophages, abietic acid suppresses production of prostaglandin E2 (PGE2) in vitro and in vivo[1].

In vivo Abietic acid has an antiobesity effect in mice mediated by the regulation of adipogenesis[2].

Protocol

Cell Research:

[3]

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  • Cell lines: CV1 cell
  • Concentrations: 0-100μM
  • Incubation Time: 24 h
  • Method:

    pM-hPPARγ, p4xUASg-tk-luc, pCMX-CBP and pRL-CMV are transfected into CV1 cells and then, 24 h after the transfection, the cells are treated with abietic acid at various concentrations for 24 h.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male C57BL/6J mice
  • Dosages: 20 mg/kg and 40 mg/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 60 mg/mL (198.37 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.45
Formula

C20H30O2

CAS No. 514-10-3
Storage powder
in solvent
Synonyms Sylvic acid, Abietate, L-Abietic acid, Rosin Acid
Smiles CC(C)C1=CC2=CCC3C(C)(CCCC3(C)C(O)=O)C2CC1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID