Allopregnanolone

Catalog No.S5805

For research use only.

Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.

Allopregnanolone Chemical Structure

CAS No. 516-54-1

Purity & Quality Control

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Biological Activity

Description Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 64 mg/mL
(200.94 mM)
Ethanol 31 mg/mL
(97.33 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 318.49
Formula

C21H34O2

CAS No. 516-54-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05129865 Recruiting Drug: LYT-300|Other: Placebo Healthy Volunteers PureTech|Novotech (Australia) Pty Limited December 7 2021 Phase 1
NCT03801629 Completed Drug: High Morphine Dose|Drug: Low Morphine Dose Drug Effect Yale University September 12 2019 Phase 1
NCT03795688 Completed Other: Pregnancy Major Depressive Disorder|Perinatal Depression Vibe G Frøkjær MD PhD|Center for Integrated Molecular Brain Imaging Copenhagen Denmak|Mental Health Centre Copenhagen|University of Copenhagen|Rigshospitalet Denmark January 24 2019 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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