Home Metabolism Amino Acids and Derivatives chemical DL-Glutamine

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DL-Glutamine Amino Acids and Derivatives chemical

Cat.No.S3963

DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.
DL-Glutamine Amino Acids and Derivatives chemical Chemical Structure

Chemical Structure

Molecular Weight: 146.14

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S396301 Water]29 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 146.14 Formula

C5H10N2O3
 

 Storage (From the date of receipt)
CAS No. 6899-04-3 Download SDF Storage of Stock Solutions

Solubility

In vitro
Batch:

Water : 29 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

In vitro
L-Glutamine is important as a precursor for peptide and protein synthesis, amino sugar synthesis, purine and pyrimidine and thus nucleic acid and nucleotide synthesis, as well as providing a source of carbons for oxidation in some cell. Glutamine has been reported to enhance many functional parameters of immune cells such as T-cell proliferation, B-lymphocyte differentiation, macrophage phagocytosis, antigen presentation and cytokine production plus neutrophil superoxide production and apoptosis. Glutamine itself may act as a key precursor for nucleic acids and nucleotides in glutamine-consuming cells, but in many physiological circumstances acts to provide glutamate, which appears to promote a wider array of metabolic functions compared to glutamine[1].
In vivo
L-Glutamate is the most abundant intracellular amino acid whereas L-glutamine is the most abundant extracellular amino acid in vivo. Glutamine metabolism is zoned in the liver so that glutamine is taken up by the periportal cells of the liver in which there is a relatively high glutaminase activity and the ammonia produced directed towards carbamoyl phosphate synthesis[1].
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06328283 Not yet recruiting
Hepatocellular Carcinoma
Sohag University
 April 1 2024 --
NCT05312736 Recruiting
Gyrate Atrophy|Gyrata of Choroid and Retina; Atrophy|Ornithine-δ-aminotransferase|OAT|Chorioretinal Degeneration
Jaeb Center for Health Research|Conquering Gyrate Atrophy Foundation|Food and Drug Administration (FDA)|Department of Health and Human Services
 November 21 2023 --
NCT05972291 Recruiting
Gulf War Illness|Irritable Bowel Syndrome|Gastrointestinal Symptoms
VA Office of Research and Development
 October 16 2023 Not Applicable

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