DL-Glutamine

Catalog No.S3963 Synonyms: Glutamin, 2-amino-4-carbamoylbutanoic acid

For research use only.

DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.

DL-Glutamine Chemical Structure

CAS No. 6899-04-3

Purity & Quality Control

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Biological Activity

Description DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.
In vitro

L-Glutamine is important as a precursor for peptide and protein synthesis, amino sugar synthesis, purine and pyrimidine and thus nucleic acid and nucleotide synthesis, as well as providing a source of carbons for oxidation in some cell. Glutamine has been reported to enhance many functional parameters of immune cells such as T-cell proliferation, B-lymphocyte differentiation, macrophage phagocytosis, antigen presentation and cytokine production plus neutrophil superoxide production and apoptosis. Glutamine itself may act as a key precursor for nucleic acids and nucleotides in glutamine-consuming cells, but in many physiological circumstances acts to provide glutamate, which appears to promote a wider array of metabolic functions compared to glutamine[1].

In vivo L-Glutamate is the most abundant intracellular amino acid whereas L-glutamine is the most abundant extracellular amino acid in vivo. Glutamine metabolism is zoned in the liver so that glutamine is taken up by the periportal cells of the liver in which there is a relatively high glutaminase activity and the ammonia produced directed towards carbamoyl phosphate synthesis[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Water 29 mg/mL
(198.43 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 146.14
Formula

C5H10N2O3
 

CAS No. 6899-04-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(=O)N)C(C(=O)O)N

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04785989 Not yet recruiting Other: [U-13C]glucose|Other: [13C5]glutamine Chronic Lymphocytic Leukemia University of Wisconsin Madison January 2022 Early Phase 1
NCT04671836 Not yet recruiting Drug: Lorazepam 1Mg Tablet|Drug: Placebo Lorazepam|Neuroimaging Northwell Health January 2022 Early Phase 1
NCT04735172 Not yet recruiting Other: specific MRI Acquisition (NMR spectroscopy) at 7T Parkinson''s Disease University Hospital Clermont-Ferrand September 2021 Not Applicable
NCT04953780 Recruiting Drug: Calaspargase pegol-mknl Acute Myeloid Leukemia University of Maryland Baltimore September 27 2021 Phase 1
NCT04641663 Enrolling by invitation Dietary Supplement: Multi-target Dietary Supplement (MTDS) Aging|Age-related Cognitive Decline Douglas Boreham|McMaster University|Northern Ontario School of Medicine September 3 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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