Home Metabolism P450 (e.g. CYP17) inhibitor Cedrol

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Cedrol P450 (e.g. CYP17) inhibitor

Cat.No.S4938

Cedrol, a natural occuring sesquiterpene alcohol, is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while this compound only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities.
Cedrol P450 (e.g. CYP17) inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 222.37

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Quality Control

Batch: S493801 DMSO]44 mg/mL]false]]]false]]]false Purity: 98%
98

Solubility

In vitro
Batch:

DMSO : 44 mg/mL (197.86 mM)
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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 222.37 Formula

C15H26O

 Storage (From the date of receipt)
CAS No. 77-53-2 -- Storage of Stock Solutions

Synonyms N/A Smiles CC1CCC2C13CCC(C(C3)C2(C)C)(C)O

Mechanism of Action

Targets/IC50/Ki
PAF (Platelet-activating factor)
CYP2B6
(Cell-free assay)
0.9 μM(Ki)
CYP3A4
(Cell-free assay)
3.4 μM(Ki)
In vitro
Cedrol is an anti-inflammatory constituent, anti-microbial ingredient and antibiosis agent. This compound could accelerate fibroblast growth in a dose-dependent manner and increase the production of type 1 collagen and elastin. Phosphorylation of p42/44 extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and Akt are also markedly increased by the treatment of this chemical, indicating that it stimulates ECM production. It is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities.
In vivo
Cedrol can promote hair reproduction. It promotes hair regeneration and shortens the telogen phase of hair follicles after alopecia occurs. This compound may possess a latent ability of preventing damage to initiatory hair follicle and restoring the morphological characteristics of follicles after they have been damaged by chemotherapy. It is a PAF antagonist that can reduce or inhibit platelet aggregation, skin inflammation, and vascular disorders.
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