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Catalog No.S2399 Synonyms: Ampeloptin

6 publications

Dihydromyricetin Chemical Structure

CAS No. 27200-12-0

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

Selleck's Dihydromyricetin has been cited by 6 publications

3 Customer Reviews

  • ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation.

    Food Chem Toxicol 2012 50, 2508-2514. Dihydromyricetin purchased from Selleck.

    A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.

    Oncotarget, 2016, 7(37):59691-59703. Dihydromyricetin purchased from Selleck.

  • Immunofluorescence staining showing that the protein levels of β-catenin are upregulated by dihydromyricetin addition (0.1 or 50 μM) at day 3 of osteogenic differentiation. β-catenin are stained red. Nuclei are stained with DAPI (blue). Scale bar = 50 μm.

    Fundam Clin Pharmacol, 2016, 30(6):596-606. Dihydromyricetin purchased from Selleck.

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Biological Activity

Description Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
GABAA receptor [1]
In vitro

Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. [1] DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. [2]

In vivo Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. [2] LD50: Mice 1.41g/kg (i.p.) [3]


Solubility (25°C)

In vitro DMSO 64 mg/mL (199.84 mM)
Ethanol 64 mg/mL (199.84 mM)
Water Insoluble

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Chemical Information

Molecular Weight 320.25


CAS No. 27200-12-0
Storage powder
in solvent
Synonyms Ampeloptin
Smiles C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID