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Gossypol Dehydrogenase inhibitor

Name: Gossypol
Brand: Selleck Chemicals
SKU: S6852
Availability: InStock
Rating: 5 (6 reviews)

Cat.No.S6852

Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. This compound is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. It also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. This chemical induces apoptosis and cell growth inhibition in various cancer cells.

Chemical Structure

Molecular Weight: 518.55

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Quality Control

Batch: S685201 DMSO]100 mg/mL]false]Ethanol]8 mg/mL]false]Water]Insoluble]false Purity: 99.56%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS/MSDS
Datasheet

99.56

Related Targets	Bcl-2 Caspase PD-1/PD-L1 Ferroptosis p53 Apoptosis related Synthetic Lethality STAT TNF-alpha Ras
Other Dehydrogenase Inhibitors	Vorasidenib (AG-881) (R)-GNE-140 CPI-613 (Devimistat) Glycyrrhizin (Glycyrrhizic Acid, NSC 167409) Sodium Dichloroacetate (DCA) AGI-6780 Emodin Gossypol Acetate AGI-5198 Brequinar (DUP785)

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (192.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (9.64mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (1.37mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	518.55	Formula	C₃₀H₃₀O₈	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	303-45-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	BL 193			SMILES	CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Bcl-xL (Cell-free assay) 0.4 μM 3α-hydroxysteroid dehydrogenase (Cell-free assay) 0.52 μM 5α-reductase 1 (Cell-free assay) 3.33 μM Bcl-2 (Cell-free assay) 10 μM
References	[1] https://pubmed.ncbi.nlm.nih.gov/15657350/ [2] https://pubmed.ncbi.nlm.nih.gov/30605780/ [3] https://pubmed.ncbi.nlm.nih.gov/12818369/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-01-13)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07337551	NOT_YET_RECRUITING	Patients With Metastatic Colorectal Cancer Who Were TP53-mutant and LRPPRC-positive and Had Previously Failed Prior First-line Treatment	Guiying Wang	2026-02-01	PHASE2
NCT07656766	NOT_YET_RECRUITING	Advanced Colorectal Cancer	Peking University People's Hospital	2026-07-15	PHASE2
NCT06133088	UNKNOWN	Advanced HR-positive and HER2-negative Breast Cancer; CDK4/6 Inhibitor Treatment Failed	Zhejiang Cancer Hospital	2023-08-01	PHASE2
NCT01003769	TERMINATED	Recurrent Chronic Lymphocytic Leukemia	Mayo Clinic	2015-07-09	PHASE1; PHASE2
NCT02697344	COMPLETED	Recurrent Plasma Cell Myeloma	Mayo Clinic	2016-04-14	PHASE1
NCT01977209	UNKNOWN	Non-small Cell Lung Cancer	Third Military Medical University	2013-09	PHASE3

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