Gossypol

For research use only.

Catalog No.S6852 Synonyms: BL 193

2 publications

Gossypol Chemical Structure

CAS No. 303-45-7

Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.

Selleck's Gossypol has been cited by 2 publications

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Biological Activity

Description Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.
Targets
Bcl-xL [3]
(Cell-free assay)
3α-hydroxysteroid dehydrogenase [2]
(Cell-free assay)
5α-reductase 1 [2]
(Cell-free assay)
Bcl-2 [3]
(Cell-free assay)
0.4 μM 0.52 μM 3.33 μM 10 μM

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (192.84 mM)
Ethanol 8 mg/mL (15.42 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 518.55
Formula

C30H30O8

CAS No. 303-45-7
Storage powder
in solvent
Synonyms BL 193
Smiles CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID