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Eleutheroside B

Name: Eleutheroside B
Brand: Selleck Chemicals
SKU: S3841
Rating: 5 (1 reviews)

Synonyms: syringin, Syringoside, Lilacin

Catalog No.S3841 Purity: 99.11%

Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.

Eleutheroside B Chemical Structure

CAS: 118-34-3

Purity & Quality Control

Batch: S384101 DMSO] 74 mg/mL] false] ] ] false] ] ] false Purity: 99.11%

99.11

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Biological Activity

Description	Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.

In vitro
In vitro	Syringin shows low cytotoxicity on the U937 and PBMC cells with IC50 of >100 and 91.14 mg/mL, respectively^[1].

In Vivo
In vivo	Syringin has a potent protection against LPS/D-GalN-induced fulminant hepatic failure (FHF), as indicated by the decreased high lethality, alleviates hepatic pathological injury, inhibits hepatocytes apoptosis and reduces hepatic inflammatory responses. Such protective effects are probably carried out through suppression of TNF-α production, which is mediated by NF-kB^[2]. Syringin also protects against LPS-induced acute lung injury (ALI) by activating Nrf2 and inhibiting NF-κB signaling pathway^[3]. Syringin improves glucose tolerance without increased weight gain in high-fat diet-induced obese mice. It augmentes insulin-stimulated Akt phosphorylation in skeletal muscle, epididymal adipose tissue (EAT), and the liver, showing an insulin-sensitizing activity. Syringin-treated mice also show markedly elevated adiponectin production in EAT and suppresses expression of pro-inflammatory cytokines in peripheral tissues, indicating a significant reduction in low-grade chronic inflammation. Additionally, syringin enhances AMP-activated protein kinase activity and decreases the expression of lipogenic genes in skeletal muscle, which is associated with reduced endoplasmic reticulum (ER) stress^[4].
Animal Research	Animal Models	BALB/c mice
	Dosages	10, 30 and 100 mg/kg
	Administration	i.p.

References

[4] Kim B, et al. Biochem Biophys Res Commun. 2017, 488(1):40-45.

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Chemical Information & Solubility

Molecular Weight	372.37	Formula	C₁₇H₂₄O₉
CAS No.	118-34-3	SDF	Download Eleutheroside B SDF
Smiles	COC1=CC(=CC(=C1OC2C(C(C(C(O2)CO)O)O)O)OC)C=CCO
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 74 mg/mL ( (198.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

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