Home Immunology & Inflammation Immunology & Inflammation related chemical Eleutheroside B

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Eleutheroside B Immunology & Inflammation related chemical

Cat.No.S3841

Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
Eleutheroside B Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 372.37

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Quality Control

Batch: S384101 DMSO]74 mg/mL]false]]]false]]]false Purity: 99.11%
99.11

Solubility

In vitro
Batch:

DMSO : 74 mg/mL (198.72 mM)
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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 372.37 Formula

C17H24O9

 Storage (From the date of receipt)
CAS No. 118-34-3 Download SDF Storage of Stock Solutions

Synonyms syringin, Syringoside, Lilacin Smiles COC1=CC(=CC(=C1OC2C(C(C(C(O2)CO)O)O)O)OC)C=CCO

Mechanism of Action

In vitro
Syringin shows low cytotoxicity on the U937 and PBMC cells with IC50 of >100 and 91.14 mg/mL, respectively.
In vivo
Syringin has a potent protection against LPS/D-GalN-induced fulminant hepatic failure (FHF), as indicated by the decreased high lethality, alleviates hepatic pathological injury, inhibits hepatocytes apoptosis and reduces hepatic inflammatory responses. Such protective effects are probably carried out through suppression of TNF-α production, which is mediated by NF-kB. Syringin also protects against LPS-induced acute lung injury (ALI) by activating Nrf2 and inhibiting NF-κB signaling pathway. Syringin improves glucose tolerance without increased weight gain in high-fat diet-induced obese mice. It augmentes insulin-stimulated Akt phosphorylation in skeletal muscle, epididymal adipose tissue (EAT), and the liver, showing an insulin-sensitizing activity. Syringin-treated mice also show markedly elevated adiponectin production in EAT and suppresses expression of pro-inflammatory cytokines in peripheral tissues, indicating a significant reduction in low-grade chronic inflammation. Additionally, syringin enhances AMP-activated protein kinase activity and decreases the expression of lipogenic genes in skeletal muscle, which is associated with reduced endoplasmic reticulum (ER) stress.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/28476623/

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