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Thioctic acid

Name: Thioctic acid
Brand: Selleck Chemicals
SKU: S3996
Rating: 5 (1 reviews)

Synonyms: DL-α-Lipoic Acid

Catalog No.S3996 Purity: 98.96%

Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form.

Thioctic acid Chemical Structure

CAS: 1077-28-7

Purity & Quality Control

Batch: Purity: 98.96%

98.96

Thioctic acid Related Products

Biological Activity

Description	Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form.

In Vivo
In vivo	Thioctic acid is a potent biological antioxidant and a detoxification agent for treating diabetic neuropathy, improving age-associated cardiovascular, cognitive, and neuromuscular deficits, and as a modulator of various inflammatory signaling pathways. Systemic administration of thioctic acid has a neuroprotective activity in brain areas^[1].
Animal Research	Animal Models	Twenty-week-old male SHR and age-matched WKY rats
	Dosages	125 μmol/kg/day and 250 μmol/kg/day
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01808300	Completed	Healthy	Unimed Pharmaceuticals	February 2013	Phase 1

References

[1] Daniele Tomassoni, et al. Int J Mol Sci. 2013, 14(3): 4580–4595.

Chemical Information & Solubility

Molecular Weight	206.33	Formula	C₈H₁₄O₂S₂
CAS No.	1077-28-7	SDF	--
Smiles	C1CSSC1CCCCC(=O)O
Storage (From the date of receipt)	3 years -20°C powder (seal)	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder (seal)		1 month-20°Cin solvent

In vitro
Batch:

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In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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