Thioctic acid

Catalog No.S3996 Synonyms: DL-α-Lipoic Acid

For research use only.

Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form.

Thioctic acid Chemical Structure

CAS No. 1077-28-7

Purity & Quality Control

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Biological Activity

Description Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form.
In vivo Thioctic acid is a potent biological antioxidant and a detoxification agent for treating diabetic neuropathy, improving age-associated cardiovascular, cognitive, and neuromuscular deficits, and as a modulator of various inflammatory signaling pathways. Systemic administration of thioctic acid has a neuroprotective activity in brain areas[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Twenty-week-old male SHR and age-matched WKY rats
  • Dosages: 125 μmol/kg/day and 250 μmol/kg/day
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 41 mg/mL
(198.71 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 206.33
Formula

C8H14O2S2

CAS No. 1077-28-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CSSC1CCCCC(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01808300 Completed Drug: Pregabalin 300mg Thioctic acid 600mg Healthy Unimed Pharmaceuticals February 2013 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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