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Gibberellic acid

Name: Gibberellic acid
Brand: Selleck Chemicals
SKU: S4766
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4766

Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound.

Chemical Structure

Molecular Weight: 346.37

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Quality Control

Batch: S476601 DMSO]69 mg/mL]false]]]false]]]false Purity: 98%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

Related Targets	PROTAC Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell Antibiotics for Mammalian Cell Culture ADC Linker Molecular Glues Antibiotics for Plant Cell Culture PROTAC Linker
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Solubility

In vitro
Batch:

DMSO : 69 mg/mL (199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	346.37	Formula	C₁₉H₂₂O₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	77-06-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Gibberellin, Gibberellin A3, GA3			Smiles	CC12C(C=CC3(C1C(C45C3CCC(C4)(C(=C)C5)O)C(=O)O)OC2=O)O

Mechanism of Action

In vivo

Gibberellic acid (GA3) acts as an agonist of steroidogenesis in male rats. Administration of this compound to rat causes reduction in liver carbohydrates, total protein content, serum levels of aspartate and alanine amino transferases and alkaline phosphatase in a time- and dose- dependent mannner. It is reported that this chemical causes hepatonephrotoxicity, oxidative stress and DNA damage in rat testis. Abscisic acid and this compound have been found to affect sexual differentiation and other physiological characteristics in mice. This chemical is tested by various routes in mice for its acute toxicity and found to be essentially nontoxic. Both subacute toxicity in mice and subchronic toxicity in dogs and rats show the compound to be asymptomatic and free of pathologic changes, histologically. The highest observed nontoxic (and asymptomatic) doses in mice as determined by acute toxicity testing are as follows: 4 Gm./Kg., intravenously; 15 Gm./Kg., orally; and 2 Gm./Kg., intraperitoneally.

References

[1] https://pubmed.ncbi.nlm.nih.gov/24079456/

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