Sennoside B

Catalog No.S4018

Sennoside B Chemical Structure

Molecular Weight(MW): 862.74

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.

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Biological Activity

Description Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Targets
PDGFR [1] PDGFR [1]
In vitro

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). [2] It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM. [1]

In vivo LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.). [3]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (115.9 mM)
Ethanol 1 mg/mL (1.15 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 862.74
Formula

C42H38O20

CAS No. 128-57-4
Storage powder
in solvent
Synonyms N/A

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PDGFR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID