For research use only.
Catalog No.S3931 Synonyms: Panaxoside Rd, Sanchinoside Rd
CAS No. 52705-93-8
Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
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|Description||Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.|
Ginsenoside Rd is a selective and competitive Ca2+ receptor antagonist and herefore, can suppress calcium influx after cytotoxic injuries. Ginsenoside Rd administration dose-dependently suppresses glutamate-induced DNA laddering and apoptosis through the suppression of glutamate-induced caspase-3 activation and Ca2+ entry. Exposure to ginsenoside Rd can also protect mitochondria against calcium-induced damages through downregulation of reactive oxygen species generation, suppression of mitochondrial membrane potential hyperpolarization, and amelioration of mitochondrial swelling. Ginsenoside Rd is a potent in vitro inhibitor on the chymotrypsin-like activity of 26S proteasome.
|In vivo||Ginsenoside Rd treatment prior to and/or following an ischemic stroke can reduce infarct volume, increase neuronal survival, and enhance cognitive and neurological functions. Ginsenoside Rd administration to a Sprague-Dawley rat has been shown to downregulate ischemic stroke-induced tau protein phosphorylation at Ser199/202 and PHF-1 sites through the downregulation of glycogen synthase kinase-3β and to enhance ischemia-induced cognitive impairment. Ginsenoside Rd administration has also been shown to upregulate the protein kinase B/AKT pathway and, from this, suppress glycogen synthase kinase-3β activity. Ginsenoside Rd administration after tMCAO upregulates glial glutamate transporter-1 (GLT-1) expression and promotes glutamate clearance in rats. Pretreatment with ginsenoside Rd (10 mg/kg) inhibits poly(ADP-ribose) polymerase-1 and consequently downregulates apoptosis-inducing factor translocation and nuclear factor-kappa B p65 subunit nuclear accumulation in Dawley rats suffering from right middle cerebral artery occlusion.|
|In vitro||DMSO||90 mg/mL (95.02 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Panaxoside Rd, Sanchinoside Rd|
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