JAK/STAT compound library

Catalog No.L5400

Offered in 96 or 384 well plate format

A unique collection of 50 small molecules used for research in JAK-STAT signaling pathway.

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

Recently the accomplishment of this research, using Selleck Chemicals library, was reported on Japanese television

You Could Select:

Specific Compounds Quantities Plate Map Dry/solid or DMSO solution

Customize Library

JAK/STAT compound library Contents

Download the JAK/STAT compound library - SDF

Download the JAK/STAT compound library - XLSX

Download the Compound Library Usage Instructions-pdf

Cited by 73 Publications

Cell Metab,2019,7;29(5):1166-1181.e6.

PubMed: 30799286 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

Nat Commun,2020,14;11(1):1792.

PubMed: 32286289 ( click the link to review the publication )

Cancer Res,2020,15;80(4):832-842.

PubMed: 31888889 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

Cell Death Dis,2020,2;11(3):158.

PubMed: 32123161 ( click the link to review the publication )

Signal Transduct Target Ther,2020,4;5:20.

PubMed: 32195002 ( click the link to review the publication )

Mol Ther Oncolytics,2020,30;17:169-179.

PubMed: 32346607 ( click the link to review the publication )

Cell Chem Biol,2020,20;27(2):197-205.e6.

PubMed: 31734178 ( click the link to review the publication )

Cell Chem Biol,2020,16;27(1):94-104.e5.

PubMed: 31902676 ( click the link to review the publication )

Antimicrob Agents Chemother,2020,4;AAC.02523-19.

PubMed: 32366713 ( click the link to review the publication )

Toxicol Sci,2020,1;174(2):218-240.

PubMed: 32040181 ( click the link to review the publication )

Int J Mol Sci,2020,18;21(8):2825.

PubMed: 32325639 ( click the link to review the publication )

Sci Rep,2020,24;10(1):5318.

PubMed: 32210281 ( click the link to review the publication )

J Biol Chem,2020,27;jbc.RA120.012981.

PubMed: 32461254 ( click the link to review the publication )

Breast Cancer Res Treat,2020,179(2):337-347.

PubMed: 31655920 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

J Allergy Clin Immunol,2020,21;S0091-6749(20)30259-1.

PubMed: 32088305 ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/2020.05.26.117770

PubMed: No ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Cell Rep,2019,5;26(6):1544-1556.e8.

PubMed: 30726737 ( click the link to review the publication )

Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )
Cancers (Basel),2019,30;11(2):156.

PubMed: 30704052 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )

Cell Chem Biol,2019,21;26(2):235-243.e5.

PubMed: 30527999 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )

Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

Int J Parasitol Drugs Drug Resist,2019,10:28-37.

PubMed: 31015150 ( click the link to review the publication )

J Med Virol,2019,91(8):1440-1447.

PubMed: 30900754 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

bioRxiv,2019,doi:10.1101/748129

PubMed: no ( click the link to review the publication )

Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

EBioMedicine,2018,28:80-89.

PubMed: 29396295 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

Sci Rep,2018,21;8(1):14178.

PubMed: 30242186 ( click the link to review the publication )

J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )
Methods Mol Biol,2018,1795:203-221.

PubMed: 29846930 ( click the link to review the publication )

Nat Commun,2017,17;8:16078.

PubMed: 28714472 ( click the link to review the publication )

Lab Chip,2017,31;17(3):511-520.

PubMed: 28092382 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )

Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

PLoS One,2017,5;12(1):e0169407.

PubMed: 28056055 ( click the link to review the publication )

Parasitol Res,2017,116(10):2619-2626.

PubMed: 28776226 ( click the link to review the publication )

Biol Pharm Bull,2017,40(8):1289-1298.

PubMed: 28769010 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

Biogerontology,2016,17(5-6):907-920.

PubMed: 27484416 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )

Database (Oxford),2016,7;2016:baw041.

PubMed: 27055828 ( click the link to review the publication )

Genome Biol,2015,19;16(1):127.

PubMed: 26084335 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Cancer Discov,2015,5(2):154-67.

PubMed: 25501949 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )

PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )
Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):
Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):
Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):
Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):
Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):
Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):
Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

• A unique collection of 50 small molecule compounds for high throughput screening(HTS) and high content screening (HCS)

• A useful tool for research in JAK-STAT signaling pathway

• For studying human diseases, exploring the pathogenesis of diseases

such as cancer, and opening noval therapeutic ways

• Structurally diverse, medicinally active, and cell permeable

• Rich documentation with structure description, target information, IC₅₀

values and customer reviews

• NMR and HPLC validated to ensure high purity

Product Details

Formulation:	50 compounds pre-dissolved in 10mM DMSO
Container:	96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:	12 months -20°C in DMSO
Stability:	24 months -80°C in DMSO
Shipping:	Blue ice or dry ice
Packaging:	Inert gas

JAK/STAT compound library Composition

HTS Facility Partners

See Other Libraries

FDA-approved Drug Library

A unique collection of 2697 approved drugs for high throughput screening (HTS) and high content screening (HCS).
FDA-approved & Passed Phase I Drug Library

A unique collection of 2991 drugs that are marketed around the world or have passed clinical phase 1 and can be used for high throughput screening (HTS) and high content screening (HCS).
Preclinical/Clinical Compound Library

A unique collection of 2814 preclinical and clinical compounds for high throughput screening (HTS) and high content screening (HCS).
Bioactive Compound Library-I

A unique collection of 7120 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).
Bioactive Compound Library-Ⅱ

A unique collection of 5309 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).
Kinase Inhibitor Library

A unique collection of 1525 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).
Express-Pick Library

A unique collection of 4208 chemical compounds featured different core structures and structural diversities respectively for high throughput screening (HTS) and high content screening (HCS).
Natural Product Library

A unique collection of 2266 natural products for high throughput screening (HTS) and high content screening (HCS).
Human Endogenous Metabolite Compound Library

541 small collections of human endogenous metabolites, involving multiple metabolic pathways, which can be used for high-throughput screening, opening up new ways for humans to treat various diseases such as tumors.
Alkaloid Compound Library

A unique collection of 269 alkaloid compounds used for high throughput screening(HTS) and high content screening(HCS).
Angiogenesis Related compound Library

A unique collection of 232 small molecules used for angiogenesis research targeting Bcr-Abl,BTK,HIF,VEGFR,FGFR,FAK,etc.
Anti-Aging Compound Library

A unique collection of 1499 anti-aging compounds used for aging related research.
Anti-alzheimer Disease Compound Library

A unique collection of 485 small molecules for exploring the mechanism of alzheimer's disease.
Antibiotics compound Library

A unique collection of 307 antibiotics used for anti- research in order to identify drug target and open up new mechanism and ways to treat human disease.
Anti-cancer Compound Library

A unique collection of 3550 anti-cancer compounds for multiple cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc.
Anti-cancer Compound Library (Verified by Broad Institute)

A unique collection of 922 compounds with anticancer activity which has been verified by broad institute,half of the compounds are non-oncology drugs.
Anti-cancer Metabolism Compound Library

A unique collection of 194 small molecules for cancer metabolism research.
Anti-Cardiovascular Disease Compound Library

A unique collection of 700 anti-cardiovascular disease related compounds used for high throughput screening(HTS) and high content screening(HCS).
Anti-diabetic Compound Library

A unique collection of 150 small molecules for exploring the development of diabetes.
Anti-infection Compound Library

A unique collection of 927 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc.
Antioxidant Compound Library

A unique collection of 426 compounds used for exploring the relationship between anti-oxidation and some diseases such as aging,cancer,alzheimer's disease,parkinson's disease,diabetes,etc.
Anti-parasitic Compound Library

A unique collection of 171 anti-parasitic compounds used for high throughput screening(HTS) and high content screening(HCS).
Antiviral Compound Library

A unique collection of 347 antiviral compounds used for exploring novel antiviral drug.
Apoptosis Compound Library

A unique collection of 978 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.
Autophagy Compound Library

A unique collection of 998 small molecules with autophagy-inducing or autophagy-inhibiting activity.
Cambridge Cancer Compound Library

A unique collection of 247 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS).
Cell Cycle compound library

A unique collection of 120 small molecule compounds used for cell cycle and related diseases research.
CNS-Penetrant Compound Library

A unique collection of 307 CNS-Penetrant compounds with biological activity for neurologic research.
Covalent Inhibitor Library

A unique collection of 81 covalent Inhibitors for high throughput screening (HTS) and high content screening (HCS).
Cytoskeletal Signaling Pathway Compound Library

A unique collection of 184 compounds used for research in cytoskeleton and cytoskeletal interactions.
DNA Damage/DNA Repair compound Library

A unique collection of 511 small molecules used for DNA Damage and Repair research with targeting PARP,ATM/ATR,Topoisomerase,DNA/RNA Synthesis etc.
Drug-like Compound Library

A unique collection of 2081 drug-like compounds used for high throughput screening(HTS) and high content screening(HCS).
Epigenetics Compound Library

A unique collection of 606 compounds with biological activity used for epigenetic research and associated assays.
FDA-approved Anticancer Drug Library

A unique collection of 1567 approved drugs with anticancer activity used for high throughput screening(HTS) and high content screening(HCS).
Ferroptosis Compound Library

A unique collection of 547 compounds used for exploring the mechanism of ferroptosis which is an iron-dependent form of non-apoptotic cell death.
Flavonoid Compound Library

A unique collection of 185 flavonoid compounds used for high throughput screening(HTS) and high content screening(HCS).
Fragment Library

A unique collection of 1015 Fragment compounds for Fragment-Based Drug Discovery (FBDD).
Glutamine Metabolism Compound Library

A unique collection of 236 glutamine metabolism related compounds used for high throughput screening (HTS) and high content screening (HCS).
GPCR Compound Library

A unique collection of 1086 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS).
Gut Microbial Metabolite Library

A unique collection of 91 gut microbial metabolites used for high throughput screening(HTS) and high content screening(HCS).
HIF-1 Signaling Pathway Compound Library

A unique collection of 447 HIF-1 signaling pathway compounds used for oxygen sensing related research.
Highly Selective Inhibitor Library

A unique collection of 339 validated highly selective inhibitors with covering over 123 targets.
Histone modification compound library

A unique collection of 199 small molecule compounds with biological activity used for histone modification research and associated assays.
HTS Library for Drug Discovery

A unique collection of 99040 compounds features numerous structurally diverse compounds and several alternate compositions.
Immunology/Inflammation Compound Library

A unique collection of 1834 small molecules with biological activity used for Immunology/Inflammation research and associated assays.
Inhibitor Library

A unique collection of 3456 inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ion Channel Ligand Library

A unique collection of 231 small molecule modulators used for Ion channel research.
Macrocyclic Compound Library

A unique collection of 106 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS).
MAPK Inhibitor Library

A unique collection of 175 small molecule inhibitors used for MAPK signaling research.
Medicine Food Homology Compound Library

A unique collection of 376 medicine food homology compounds used for high throughput screening (HTS) and high content screening (HCS).
Metabolism Compound Library

A unique collection of 2024 small molecules with biological activity in numerous metabolic pathway: glycometabolism, lipid metabolism, proteolysis, etc.
Methylation Compound Library

A unique collection of 112 compounds used for researching the function of methylation in epigenetics,cancer,embryogenesis,etc.
Natural Organic Compound Library

A unique collection of 1127 plant-derived natural organic compounds used for high throughput screening(HTS) and high content screening(HCS).
Neuronal Signaling Compound Library

A unique collection of 1093 small molecule compounds with biological activity used for neurologic research and associated assays
NF-κB Signaling Compound Library

A unique collection of 310 small molecules used for NF-κB signaling pathway research which plays a key role in immunology/inflammation and cancer.
Nucleoside Analogue Library

A unique collection of 135 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
Obesity Compound Library

A unique collection of 936 compounds used for research in obesity.
PI3K/Akt Inhibitor Library

A unique collection of 261 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.
Protease Inhibitor Library

A unique collection of 227 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and high content screening (HCS).
Protein-protein Interaction Inhibitor Library

A unique collection of 188 protein-protein Interaction(PPI) Inhibitors used for high throughput screening(HTS) and high content screening(HCS).
Pyroptosis Compound Library

A unique collection of 441 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS).
Small Molecule Immuno-Oncology Compound Library

A unique collection of 122 Immuno-Oncology small molecules used for oncotherapy in conjunction with other drugs.
Stem Cell Signaling Compound Library

A unique collection of 491 compounds with biological activity used for stem cell regulatory and signaling pathway research.
TGF-beta/Smad compound library

A unique collection of 105 small molecules with biological activity used for TGF-beta/Smad pathway research.
Traditional Chinese Medicine Library

A unique collection of 1044 traditional chinese medicine(TCM) monomer compounds used for high throughput screening(HTS) and high content screening(HCS).
Tyrosine Kinase Inhibitor Library

A unique collection of 390 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ubiquitination Compound Library

A unique collection of 151 small molecules for Ubiquitination related research.

Choose Your Country or Region

By Signaling Pathways

By product type