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Leonurine Autophagy chemical

Cat.No.S3890

Leonurine, an active alkaloid extracted from Traditional Chinese Medicine Herba leonuri, exerts several biological effects, such as antidiabetic, cardiovascular, and bovine mastitis protection.
Leonurine Autophagy chemical Chemical Structure

Chemical Structure

Molecular Weight: 311.33

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Quality Control

Batch: S389001 DMSO]Insoluble]false]]]false]]]false Purity: 99.74%
99.74

Chemical Information, Storage & Stability

Molecular Weight 311.33 Formula

C14H21N3O5

 Storage (From the date of receipt)
CAS No. 24697-74-3 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC(=CC(=C1O)OC)C(=O)OCCCCN=C(N)N

Solubility

In vitro
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DMSO : Insoluble
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In vivo
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Mechanism of Action

In vitro
Leonurine inhibits U937 cells adhesion to TNF-α-activated HUVEC in a concentration dependent manner. Treatment with this compound blocks TNF-α-induced mRNA and protein expression of adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1), cyclooxygenase-2, and monocyte chemoattractant protein-1 in endothelial cells. In addition, this compound attenuates TNF-α-induced intracellular ROS production in HUVEC. Furthermore, it suppresses the TNF-α-activated p38 phosphorylation and IκBα degradation. Subsequently reduced NF-κB p65 phosphorylation, nuclear translocation, and DNA-binding activity are also observed[1]. This chemical attenuates DOX-induced apoptosis in H9c2 cell by increasing anti-oxidant, anti-apoptotic ability and protecting mitochondrial function[4].
In vivo
Leonurine attenuates hyperalgesia in mice with induced adenomyosis via down-regulating expressions of p-P65, COX-2, and OTR, and could be beneficial for treating adenomyosis[2]. This compound exerts antidepressant-like effects, which may be mediated, at least in part, by improving monoamine neurotransmitters and inhibiting neuroinflammation. It possesses neuroprotective effects in animal models of ischemic stroke, parkinson's disease, and alzheimer's disease. This chemical treatment significantly rescues behavioral deficit of animals, promotes neuronal survival, and inhibits inflammation[3].
References

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