Tanshinone IIA

Catalog No.S2365 Synonyms: Tanshinone B

Tanshinone IIA Chemical Structure

Molecular Weight(MW): 294.34

Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.

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2 Customer Reviews

  • Western blotting analysis of b-catenin, TCF3 and LEF1 levels in HT-29 cells. b-actin is the loading control.

    Cancer Lett, 2017, 403:86-97. Tanshinone IIA purchased from Selleck.

    The nuclear-cytoplasmic translocation of HuR was examined in Cervical cancer cells with Tanshinone IIA treatment by Immunofluorescent assay.

    Biomed Pharmacother, 2018, 105:758-765. Tanshinone IIA purchased from Selleck.

Purity & Quality Control

Choose Selective Lipase Inhibitors

Biological Activity

Description Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.
Targets
monoacylglycerol lipase [4]
In vitro

Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases. Tanshinone IIA protects cardiac myocytes against oxidative stress-induced apoptosis. The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio. [1] Recently, tanshinone IIA was demonstrated to induce cell death and apoptosis in a variety of tumors. [2]

In vivo LD50: Rats 25g/kg (i.g.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 5 mg/mL (16.98 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
0.2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 294.34
Formula

C19H18O3

CAS No. 568-72-9
Storage powder
in solvent
Synonyms Tanshinone B

Bio Calculators

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID