Propyl gallate

Catalog No.S5113 Synonyms: Gallic acid propyl esterZ, n-Propyl gallate

For research use only.

Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.

Propyl gallate Chemical Structure

CAS No. 121-79-9

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Biological Activity

Description Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.
In vitro

Propyl gallate (PG) could modulate heme oxygenase-1 (HO-1) activation and decrease lung cancer cell survival. Propyl gallate also induces apoptosis in human leukemia cells and HeLa cells by increasing reactive oxygen species (ROS) levels and glutathione (GSH) depletion. Propyl gallate inhibits the expression of MMP-2 and MMP-9 and exerts an antimigration effect on TMZ-treated U87MG cells. Propyl gallate also possesses anti-inflammatory activity via downregulation of the NF-κB pathway. Propyl gallate could reduce the proliferation and augment the chemosensitivity of a THP-1 leukemia cell line via extrinsic and intrinsic apoptotic pathways[1].

In vivo In brain ischemia, Propyl gallate inhibits the activity of NF-κB, reduces COX-2 and TNF-alpha G expression, and decreases ischemic-reperfusion injury[1].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: U87MG glioma cells
  • Concentrations: 50 or 100 μM
  • Incubation Time: 48 h
  • Method: U87MG cells (1 × 104) are seeded in each well of a 96-well cultured plate for 24 h and then treated with TMZ (200 μM), PG (50 or 100 μM), or their combination for 48 h. After treatment, cell viability is determined by an XTT-based assay.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 42 mg/mL
(197.92 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 212.20
Formula

C10H12O5

CAS No. 121-79-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCOC(=O)C1=CC(=C(C(=C1)O)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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