Home Metabolism PPAR agonist Pseudoginsenoside F11

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Pseudoginsenoside F11 PPAR agonist

Cat.No.S9199

Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.
Pseudoginsenoside F11 PPAR agonist Chemical Structure

Chemical Structure

Molecular Weight: 801.01

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Quality Control

Batch: S919901 DMSO]100 mg/mL]false]]]false]]]false Purity: 98.79%
98.79

Chemical Information, Storage & Stability

Molecular Weight 801.01 Formula

C42H72O14

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 69884-00-0 -- Storage of Stock Solutions

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (124.84 mM)
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In vivo
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Mechanism of Action

Targets/IC50/Ki
PPARγ [1]
In vitro
Pseudoginsenoside F11 (PF11) promotes the differentiation of 3T3-L1 preadipocytes. It promotes adipogenesis by activating PPARγ[1]. PF11 significantly suppresses the release of ROS and proinflammatory mediators induced by LPS in a microglial cell line N9 including NO, PGE2, IL-1β, IL-6 and TNF-α. Moreover, PF11 inhibits interaction and expression of TLR4 and MyD88 in LPS-activated N9 cells, resulting in an inhibition of the TAK1/IKK/NF-κB signaling pathway. PF11 also inhibited the phosphorylation of Akt and MAPKs induced by LPS in N9 cells[2].
In vivo
In in vivo studies, PF11 mitigated the microglial activation and proinflammatory factors expression obviously in both cortex and hippocampus in mice injected intrahippocampally with LPS. PF11 exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways. It may exert therapeutic effects for neurodegenerative disease associated with neuroinflammation[2].
References

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