Home Metabolism PPAR agonist Pseudoginsenoside F11 For research use only.

Pseudoginsenoside F11

Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.

Pseudoginsenoside F11 Chemical Structure

Pseudoginsenoside F11 Chemical Structure

CAS: 69884-00-0

Purity & Quality Control

Batch: S919901 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 98.79%
98.79

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Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

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Biological Activity

Description Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.
Targets
PPARγ [1]
In vitro
In vitro Pseudoginsenoside F11 (PF11) promotes the differentiation of 3T3-L1 preadipocytes. It promotes adipogenesis by activating PPARγ[1]. PF11 significantly suppresses the release of ROS and proinflammatory mediators induced by LPS in a microglial cell line N9 including NO, PGE2, IL-1β, IL-6 and TNF-α. Moreover, PF11 inhibits interaction and expression of TLR4 and MyD88 in LPS-activated N9 cells, resulting in an inhibition of the TAK1/IKK/NF-κB signaling pathway. PF11 also inhibited the phosphorylation of Akt and MAPKs induced by LPS in N9 cells[2].
Cell Research Cell lines 3T3-L1 preadipocytes
Concentrations 0, 20, 40 μM
Incubation Time 8 days
Method

3T3-L1 preadipocytes are induced to differentiate with 0, 20, 40 μM Pseudoginsenoside F11 (p-F11) or 0.5 μM rosiglitazone in the absence or presence of 20 μM GW9662 for 8 days.
In Vivo
In vivo In in vivo studies, PF11 mitigated the microglial activation and proinflammatory factors expression obviously in both cortex and hippocampus in mice injected intrahippocampally with LPS. PF11 exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways. It may exert therapeutic effects for neurodegenerative disease associated with neuroinflammation[2].
Animal Research Animal Models male C57BL/6 mice
Dosages 8 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 801.01 Formula

C42H72O14
CAS No. 69884-00-0 SDF --
Smiles CC1C(C(C(C(O1)OC2C(C(C(OC2OC3CC4(C(CC(C5C4(CCC5C6(CCC(O6)C(C)(C)O)C)C)O)C7(C3C(C(CC7)O)(C)C)C)C)CO)O)O)O)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
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DMSO : 100 mg/mL ( (124.84 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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