Pseudoginsenoside F11

Catalog No.S9199

For research use only.

Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.

Pseudoginsenoside F11 Chemical Structure

CAS No. 69884-00-0

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Biological Activity

Description Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.
Targets
PPARγ [1]
()
In vitro

Pseudoginsenoside F11 (PF11) promotes the differentiation of 3T3-L1 preadipocytes. It promotes adipogenesis by activating PPARγ[1]. PF11 significantly suppresses the release of ROS and proinflammatory mediators induced by LPS in a microglial cell line N9 including NO, PGE2, IL-1β, IL-6 and TNF-α. Moreover, PF11 inhibits interaction and expression of TLR4 and MyD88 in LPS-activated N9 cells, resulting in an inhibition of the TAK1/IKK/NF-κB signaling pathway. PF11 also inhibited the phosphorylation of Akt and MAPKs induced by LPS in N9 cells[2].

In vivo In in vivo studies, PF11 mitigated the microglial activation and proinflammatory factors expression obviously in both cortex and hippocampus in mice injected intrahippocampally with LPS. PF11 exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways. It may exert therapeutic effects for neurodegenerative disease associated with neuroinflammation[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: 3T3-L1 preadipocytes
  • Concentrations: 0, 20, 40 μM
  • Incubation Time: 8 days
  • Method:

    3T3-L1 preadipocytes are induced to differentiate with 0, 20, 40 μM Pseudoginsenoside F11 (p-F11) or 0.5 μM rosiglitazone in the absence or presence of 20 μM GW9662 for 8 days.

  • (Only for Reference)
Animal Research:

[2]

  • Animal Models: male C57BL/6 mice
  • Dosages: 8 mg/kg
  • Administration: oral
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(124.84 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 801.01
Formula

C42H72O14

CAS No. 69884-00-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1C(C(C(C(O1)OC2C(C(C(OC2OC3CC4(C(CC(C5C4(CCC5C6(CCC(O6)C(C)(C)O)C)C)O)C7(C3C(C(CC7)O)(C)C)C)C)CO)O)O)O)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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