Ursodiol

Synonyms: Ursodeoxycholic acid, UDCA

Ursodiol (Ursodeoxycholic acid, UDCA) reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM)

Ursodiol Chemical Structure

Ursodiol Chemical Structure

CAS: 128-13-2

Purity & Quality Control

Batch: S164301 DMSO] 79 mg/mL] false] Ethanol] 79 mg/mL] false] Water] Insoluble] false Purity: >97%
97

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Biological Activity

Description Ursodiol (Ursodeoxycholic acid, UDCA) reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00846963 Completed
Cholestasis
Ibrahim Mohamed|St. Justine''s Hospital
October 2008 Phase 2|Phase 3
NCT00909610 Completed
Healthy
Teva Pharmaceuticals USA
December 2006 Phase 1
NCT00909753 Completed
Healthy
Teva Pharmaceuticals USA
September 2006 Phase 1

Chemical Information & Solubility

Molecular Weight 392.57 Formula

C24H40O4

CAS No. 128-13-2 SDF Download Ursodiol SDF
Smiles CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (201.23 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 79 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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