Tetrahydroberberine

Catalog No.S5153 Synonyms: Canadine

Tetrahydroberberine Chemical Structure

Molecular Weight(MW): 339.39

Tetrahydroberberine is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.

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Biological Activity

Description Tetrahydroberberine is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
Targets
D2 receptor [1]
()
5-HT1A [1]
()
6.08(pKi) 5.38(pKi)
In vivo Oral administration of THB not only resulted in significantly accelerated gastric emptying of normal rats in a bell-shaped relationship, with a maximal efficacy at a dose of 30 μg/kg, but also restored the delayed gastric emptying caused by apomorphine, which might be mediated by an antidopaminergic effect[1].

Protocol

Animal Research:

[1]

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  • Animal Models: Male Sprague-Dawley rats (200-220 g)
  • Formulation: 3% (w/v) hydroxypropyl methylcellulose
  • Dosages: 1, 3, 10, 30, or 100 μg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 6 mg/mL (17.67 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 339.39
Formula

C20H21NO4

CAS No. 522-97-4
Storage powder
in solvent
Synonyms Canadine

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID