Synephrine

Catalog No.S2362 Synonyms: Oxedrine

Synephrine Chemical Structure

Molecular Weight(MW): 167.21

Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.

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Biological Activity

Description Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
Targets
Adrenergic Receptor [1]
In vitro

Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. [1] [2] Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells. [3]

In vivo LD50: Mice >1000mg/kg (s.c.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 33 mg/mL warmed (197.35 mM)
Ethanol 2 mg/mL warmed (11.96 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 167.21
Formula

C9H13NO2

CAS No. 94-07-5
Storage powder
in solvent
Synonyms Oxedrine

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID