Bakuchiol

Catalog No.S3813 Synonyms: (S)-(+)-Bakuchiol

Bakuchiol Chemical Structure

Molecular Weight(MW): 256.38

Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.

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Biological Activity

Description Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
In vitro

Bakuchiol inhibits EGF-induced signaling pathways downstream of Hck, Blk and p38 MAPK, including the MEK/ERKs, p38 MAPK/MSK1 and AKT/p70S6K pathways. Bakuchiol decreases viability and inhibits anchorage-independent growth of A431 human epithelial carcinoma cells. It also inhibits the proliferation of A549 human lung adenocarcinoma cells, SK-MEL-2 human melanoma cells and B16 mouse melanoma cells by inducing apoptosis[1].

In vivo Bakuchiol reduces A431 xenograft tumor growth in an in vivo mouse model[1]. Bakuchiol treatment attenuates acute lung injury following sepsis by suppressing inflammation, oxidative stress, and endothelial barrier disruption[2].

Protocol

Cell Research:

[1]

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  • Cell lines: HaCaT and JB6 P+ cells
  • Concentrations: 0, 5, 10, and 20 μM
  • Incubation Time: 1 h
  • Method:

    Cells (1.5 × 106) are cultured in 100-mm dishes for 48 h, and then serum starved in 0.1% FBS-MEM for 24 h. The cells are then treated with bakuchiol (0, 5, 10, and 20 μM) for 1 h before exposure to 10 ng/ml EGF for an additional 30 min. Cells are harvested and disrupted with lysis buffer before protein concentration is measured using a dye-binding protein assay kit.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: 6-week-old, BALB/c-nu mice
  • Formulation: 10% DMSO in PBS
  • Dosages: 10 or 40 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 256.38
Formula

C18H24O

CAS No. 10309-37-2
Storage powder
in solvent
Synonyms (S)-(+)-Bakuchiol

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID