Bakuchiol

Catalog No.S3813 Synonyms: (S)-(+)-Bakuchiol

For research use only.

Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.

Bakuchiol Chemical Structure

CAS No. 10309-37-2

Selleck's Bakuchiol has been cited by 1 Publication

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Biological Activity

Description Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
In vitro

Bakuchiol inhibits EGF-induced signaling pathways downstream of Hck, Blk and p38 MAPK, including the MEK/ERKs, p38 MAPK/MSK1 and AKT/p70S6K pathways. Bakuchiol decreases viability and inhibits anchorage-independent growth of A431 human epithelial carcinoma cells. It also inhibits the proliferation of A549 human lung adenocarcinoma cells, SK-MEL-2 human melanoma cells and B16 mouse melanoma cells by inducing apoptosis[1].

In vivo Bakuchiol reduces A431 xenograft tumor growth in an in vivo mouse model[1]. Bakuchiol treatment attenuates acute lung injury following sepsis by suppressing inflammation, oxidative stress, and endothelial barrier disruption[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: HaCaT and JB6 P+ cells
  • Concentrations: 0, 5, 10, and 20 μM
  • Incubation Time: 1 h
  • Method:

    Cells (1.5 × 106) are cultured in 100-mm dishes for 48 h, and then serum starved in 0.1% FBS-MEM for 24 h. The cells are then treated with bakuchiol (0, 5, 10, and 20 μM) for 1 h before exposure to 10 ng/ml EGF for an additional 30 min. Cells are harvested and disrupted with lysis buffer before protein concentration is measured using a dye-binding protein assay kit.

  • (Only for Reference)
Animal Research:

[1]

  • Animal Models: 6-week-old, BALB/c-nu mice
  • Dosages: 10 or 40 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Chemical Information

Molecular Weight 256.38
Formula

C18H24O

Density 0.96 g/mL
CAS No. 10309-37-2
Storage 2 years -20°C(in the dark) liquid
Smiles CC(=CCCC(C)(C=C)C=CC1=CC=C(C=C1)O)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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