Home Immunology & Inflammation Immunology & Inflammation related chemical Bakuchiol

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Bakuchiol Immunology & Inflammation related chemical

Cat.No.S3813

Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., This compound is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
Bakuchiol Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 256.38

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Quality Control

Batch: S381301 Purity: 99.96%
99.96

Solubility

In vitro
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 256.38 Formula

C18H24O

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 10309-37-2 Download SDF Storage of Stock Solutions

Mechanism of Action

In vitro
Bakuchiol inhibits EGF-induced signaling pathways downstream of Hck, Blk and p38 MAPK, including the MEK/ERKs, p38 MAPK/MSK1 and AKT/p70S6K pathways. This compound decreases viability and inhibits anchorage-independent growth of A431 human epithelial carcinoma cells. It also inhibits the proliferation of A549 human lung adenocarcinoma cells, SK-MEL-2 human melanoma cells and B16 mouse melanoma cells by inducing apoptosis.
In vivo
Bakuchiol reduces A431 xenograft tumor growth in an in vivo mouse model. This compound treatment attenuates acute lung injury following sepsis by suppressing inflammation, oxidative stress, and endothelial barrier disruption.
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