- Bioactive Compounds
- By Signaling Pathways
- PI3K/Akt/mTOR
- Epigenetics
- Methylation
- Immunology & Inflammation
- Protein Tyrosine Kinase
- Angiogenesis
- Apoptosis
- Autophagy
- ER stress & UPR
- JAK/STAT
- MAPK
- Cytoskeletal Signaling
- Cell Cycle
- TGF-beta/Smad
- Compound Libraries
- Antibodies
- Bioreagents
- qPCR
- 2x SYBR Green qPCR Master Mix
- 2x SYBR Green qPCR Master Mix(Low ROX)
- 2x SYBR Green qPCR Master Mix(High ROX)
- Protein Assay
- Protein A/G Magnetic Beads for IP
- Anti-Flag magnetic beads
- Anti-Flag Affinity Gel
- Anti-Myc magnetic beads
- Anti-HA magnetic beads
- Poly FLAG Peptide lyophilized powder
- Protease Inhibitor Cocktail
- Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO)
- Phosphatase Inhibitor Cocktail (2 Tubes, 100X)
- Cell Biology
- Cell Counting Kit-8 (CCK-8)
- Animal Experiment
- Mouse Direct PCR Kit (For Genotyping)
- New Products
- Contact Us
-
Australia
-
Austria
-
Belgium
-
Brazil
-
Canada
-
China
-
Czech Republic
-
Denmark
-
Finland
-
France
-
Germany
-
Greece
-
Hong Kong
-
Hungary
-
Iceland
-
India
-
Ireland
-
Israel
-
Italy
-
Japan
-
Korea
-
Luxembourg
-
Malaysia
-
Netherlands
-
New Zealand
-
Norway
-
Poland
-
Qatar
-
Romania
-
Saudi Arabia
-
Singapore
-
Spain
-
Sweden
-
Switzerland
-
Taiwan
-
Turkey
-
United Kingdom
-
United States
-
Other Countries
Folinic acid (Leucovorin)
Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.
Folinic acid (Leucovorin) Chemical Structure
CAS: 58-05-9
Selleck's Folinic acid (Leucovorin) has been cited by 1 publication
Purity & Quality Control
Batch:
Purity:
99.70%
99.70
Folinic acid (Leucovorin) Related Products
| Related Products | Pemetrexed Raltitrexed Trifluridine (NSC 75520) TAS-102 | Click to Expand |
|---|---|---|
| Related Compound Libraries | Autophagy Compound Library Apoptosis Compound Library Ferroptosis Compound Library Pyroptosis Compound Library Mitochondria-Targeted Compound Library | Click to Expand |
Choose Selective Thymidylate Synthase Inhibitors
Biological Activity
| Description | Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared. | |
|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05899751 | Recruiting | Acute Kidney Injury|Drug Toxicity |
Protherics Medicines Development Limited|Resonance Inc|BTG International Inc. |
April 1 2022 | -- |
| NCT04158349 | Terminated | Colorectal Cancer|Appendiceal Cancer|Peritoneal Carcinoma |
University of Utah |
March 22 2021 | Phase 1 |
| NCT05013164 | Completed | Autism Spectrum Disorder |
Nishtar Medical University |
October 1 2020 | Phase 2 |
| NCT04060030 | Recruiting | Autism Spectrum Disorder|Language Disorders |
Southwest Autism Research & Resource Center|Autism Speaks|State University of New York - Downstate Medical Center |
October 8 2020 | Phase 2 |
| NCT04060017 | Recruiting | Autism Spectrum Disorder|Language Disorders |
Southwest Autism Research & Resource Center|State University of New York - Downstate Medical Center|United States Department of Defense |
September 22 2020 | Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 473.44 | Formula | C20H23N7O7 |
| CAS No. | 58-05-9 | SDF | -- |
| Storage (From the date of receipt) | 3 years -20°C powder | Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt. | |
|
In vitro |
DMSO : 95 mg/mL ( (200.65 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : Insoluble Ethanol : Insoluble |
Molecular Weight Calculator |
|
In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
||||
Preparing Stock Solutions
Molarity Calculator
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
mg/kg
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.
* Indicates a Required Field
Tags: buy Folinic acid (Leucovorin) | Folinic acid (Leucovorin) supplier | purchase Folinic acid (Leucovorin) | Folinic acid (Leucovorin) cost | Folinic acid (Leucovorin) manufacturer | order Folinic acid (Leucovorin) | Folinic acid (Leucovorin) distributor
Products are for research use only. Not for human use. We do not sell to patients.
©Copyright 2013 Selleck Chemicals. All Rights Reserved.